{"id":"W2089489607","doi":"10.1371/journal.pone.0032053","title":"Modeling Inhomogeneous DNA Replication Kinetics","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"DNA replication; Replication (statistics); Origin of replication; Control of chromosome duplication; Origin recognition complex; Genome; Biology; Eukaryotic DNA replication; DNA; Genetics; Physics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001239113,0.001177688,0.001503158,0.001276557,0.0007445127,0.00146158,0.00234718,0.003289757,0.002307421],"category_scores_gemma":[0.0064569,0.0009724058,0.001921915,0.001158026,0.001620883,0.002042799,0.001215376,0.001606581,0.0005963705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002095968,"about_ca_system_score_gemma":0.001317947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0111018,"about_ca_topic_score_gemma":0.004549848,"domain_scores_codex":[0.9994036,0.0001490459,0.00003363012,0.0001850454,0.0001410171,0.00008769833],"domain_scores_gemma":[0.9970759,0.001974799,0.000384439,0.0001978419,0.0002434297,0.0001236074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000207866,0.00002169833,0.0004871764,0.00004459832,0.00001226618,0.00007858326,0.00005724703,0.9672797,0.00250887,0.02787154,0.0002083466,0.00140917],"study_design_scores_gemma":[0.000004645853,0.000004394346,0.00005304494,0.000002143721,0.000002980966,0.000009368597,0.000003604012,0.9959378,0.0002279065,0.003467841,0.0002813926,0.000004828781],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.178743,0.0009179818,0.8031598,0.0009245087,0.000245916,0.0001798672,0.0009025548,0.0006779659,0.01424828],"genre_scores_gemma":[0.8730691,0.001373424,0.101594,0.0004365663,0.0001849564,0.0007874094,0.001116165,0.0004013506,0.02103698],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0111018,"threshold_uncertainty_score":0.0220744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03958079348075653,"score_gpt":0.2392344094621083,"score_spread":0.1996536159813517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}