{"id":"W2089494647","doi":"10.1371/journal.pone.0079951","title":"Cathepsin B Gene Disruption Induced Leishmania donovani Proteome Remodeling Implies Cathepsin B Role in Secretome Regulation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cathepsin A; Cathepsin B; Biology; Cathepsin H; Cathepsin C; Proteome; Cathepsin L1; Cathepsin O; Cathepsin L; Mutant; Proteases; Leishmania donovani; Cathepsin D; Cathepsin; Molecular biology; Cysteine protease; Cell biology; Biochemistry; Gene; Genetics; Enzyme; Visceral leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005729647,0.000301531,0.0006500951,0.0004964278,0.0001632141,0.00009675697,0.0001866504,0.0001995134,0.0002347018],"category_scores_gemma":[0.000502608,0.000276068,0.00008459738,0.0005910961,0.00008522654,0.0005433073,0.0001729871,0.0005222722,0.0004208614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005397893,"about_ca_system_score_gemma":0.0001260263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001827583,"about_ca_topic_score_gemma":0.000244424,"domain_scores_codex":[0.9970625,0.0001235789,0.0006276252,0.0005829216,0.0009317632,0.0006716223],"domain_scores_gemma":[0.9983843,0.00007893892,0.0001692644,0.0006479858,0.0005226799,0.0001968288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001286324,0.0009843779,0.02512533,0.0002176702,0.0001496424,0.00000756151,0.001641475,0.0000171453,0.9683853,0.00007189648,0.00004659798,0.003224308],"study_design_scores_gemma":[0.002112035,0.0005671434,0.630593,0.0008053468,0.0001306865,0.00002562564,0.0008753361,0.01464955,0.347253,0.002483534,0.00003681197,0.0004678955],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922373,0.0003548764,0.0000807946,0.002986505,0.0000280157,0.002915087,0.000006909606,0.0001772485,0.001213291],"genre_scores_gemma":[0.9907987,0.0002054442,0.006777368,0.0001102722,0.0002914332,0.0007041045,0.00007110574,0.00007889721,0.0009627166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6211323,"threshold_uncertainty_score":0.9999691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06899833971954542,"score_gpt":0.2824562987386114,"score_spread":0.213457959019066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}