{"id":"W2089494647","doi":"10.1371/journal.pone.0079951","title":"Cathepsin B Gene Disruption Induced Leishmania donovani Proteome Remodeling Implies Cathepsin B Role in Secretome Regulation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cathepsin A; Cathepsin B; Biology; Cathepsin H; Cathepsin C; Proteome; Cathepsin L1; Cathepsin O; Cathepsin L; Mutant; Proteases; Leishmania donovani; Cathepsin D; Cathepsin; Molecular biology; Cysteine protease; Cell biology; Biochemistry; Gene; Genetics; Enzyme; Visceral leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008638499,0.0002742713,0.0001757737,0.0001660043,0.0001208796,0.0002832475,0.0001089941,0.000195807,0.0009560193],"category_scores_gemma":[0.0001090683,0.0001055946,0.0002181356,0.0001404778,0.0002282963,0.0001981751,0.0001440773,0.000341863,0.0001550626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155492,"about_ca_system_score_gemma":0.0001523924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004362872,"about_ca_topic_score_gemma":0.0005655045,"domain_scores_codex":[0.9999199,0.00001540766,0.000008230611,0.000020142,0.00001597376,0.00002035968],"domain_scores_gemma":[0.9999106,0.00001526224,0.00003160534,0.0000116679,0.00001109672,0.0000197978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006309139,0.00000828698,0.000615137,0.00002120443,0.000003364263,0.00006415904,0.000007395927,0.000009477061,0.9989085,0.0000258912,0.000009359936,0.0002642051],"study_design_scores_gemma":[0.00001514547,0.0001470228,0.02769635,0.000005604931,0.0000172756,0.0009857992,0.0000722956,0.0003115508,0.9693792,0.00007783817,0.001286849,0.000005142834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978383,0.0005244663,0.0008869934,0.00008014491,0.00000782807,0.000008147515,0.0002733901,0.00001990888,0.0003607665],"genre_scores_gemma":[0.9970391,0.0003254783,0.001382869,0.0000469445,0.00000213378,0.00001156929,0.0005091985,0.000008967567,0.000673786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009560193,"threshold_uncertainty_score":0.003198206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06899833971954542,"score_gpt":0.2824562987386114,"score_spread":0.213457959019066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}