{"id":"W2089506194","doi":"10.1371/journal.pone.0123987","title":"Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"PRC2; Histone H3; Biology; Cell biology; EZH2; Downregulation and upregulation; Histone methylation; Cancer research; Diabetic retinopathy; Retina; Histone methyltransferase; Histone; DNA methylation; Diabetes mellitus; Endocrinology; Genetics; Neuroscience; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208248,0.000210115,0.0001929043,0.000244135,0.0002045322,0.0003615592,0.0001933442,0.0002599018,0.00117592],"category_scores_gemma":[0.0001460931,0.0001322181,0.000161596,0.0002014443,0.0002415552,0.000196724,0.0002107632,0.0003246989,0.0002593145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946255,"about_ca_system_score_gemma":0.0001545103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007643929,"about_ca_topic_score_gemma":0.0009846156,"domain_scores_codex":[0.9999061,0.00001855612,0.00000778289,0.00002200015,0.00002315309,0.00002246785],"domain_scores_gemma":[0.9999225,0.000008995955,0.00002319117,0.00001052138,0.00001314339,0.00002164861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001776941,0.00002810022,0.001059892,0.00004658921,0.000009650586,0.0001951186,0.00003054876,0.00004024875,0.9953128,0.0003957829,0.0001031472,0.00260037],"study_design_scores_gemma":[0.00007317635,0.0003013717,0.09693633,0.00002156364,0.00005912227,0.001504103,0.0001931807,0.002609762,0.8872159,0.0006841323,0.01038291,0.00001852038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645081,0.02326204,0.005483023,0.0006828543,0.0001041433,0.00003584359,0.0004427378,0.0001497145,0.005331537],"genre_scores_gemma":[0.9948591,0.002120783,0.0006990298,0.00009691106,0.00001851643,0.00001573366,0.0001966377,0.00001033466,0.00198301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117592,"threshold_uncertainty_score":0.003933787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430437680227001,"score_gpt":0.238482020406351,"score_spread":0.204177643604081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}