{"id":"W2089510176","doi":"10.1089/hum.2012.034","title":"Transcription Activator-Like Effector Proteins Induce the Expression of the Frataxin Gene","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Effector; Gene expression; Transcription (linguistics); Gene; Cell biology; Biology; Activator (genetics); Frataxin; Regulation of gene expression; Transcription factor; Molecular biology; Genetics; Iron-binding proteins","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214787,0.0005030672,0.0003312372,0.0002393947,0.0001374208,0.0003484316,0.0002025975,0.0004407451,0.001955369],"category_scores_gemma":[0.0001730585,0.0001901936,0.0004872007,0.0001517577,0.0003463764,0.0002710872,0.0003838981,0.0008268429,0.0009649809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867436,"about_ca_system_score_gemma":0.0002026049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001918666,"about_ca_topic_score_gemma":0.0002224024,"domain_scores_codex":[0.9998465,0.00001863346,0.00001260156,0.00003720196,0.00004641397,0.00003872455],"domain_scores_gemma":[0.9998856,0.00003402309,0.00003818743,0.00001159648,0.00001174459,0.00001892197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001917627,0.000009190641,0.00005795467,0.00002862771,0.00000314871,0.00002511574,0.000008423189,0.00005758478,0.9990512,0.00009050618,0.00003246916,0.0006166678],"study_design_scores_gemma":[0.00001112203,0.00007263063,0.0006412544,0.000005018668,0.000007254296,0.0001249336,0.00001061728,0.0004478347,0.9954319,0.00006122076,0.003182899,0.000003318422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471592,0.002632595,0.0442104,0.0004198948,0.0001357775,0.0001557571,0.001075553,0.0008986437,0.003312242],"genre_scores_gemma":[0.9643222,0.001336705,0.02342658,0.0001868405,0.00002514457,0.0001159734,0.001290777,0.0001262737,0.009169462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955369,"threshold_uncertainty_score":0.006541312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06285867488829491,"score_gpt":0.28741950283485,"score_spread":0.2245608279465551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}