{"id":"W2089520557","doi":"10.1111/ocr.12080","title":"The effects of tissue‐non‐specific alkaline phosphatase gene therapy on craniosynostosis and craniofacial morphology in the FGFR2<sup>C342Y/+</sup> mouse model of Crouzon craniosynostosis","year":2015,"lang":"en","type":"article","venue":"Orthodontics and Craniofacial Research","topic":"Craniofacial Disorders and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hatch (Canada)","funders":"National Institute of Dental and Craniofacial Research; Hartwell Foundation","keywords":"Craniosynostosis; Craniofacial; Alkaline phosphatase; Crouzon syndrome; Synostosis; Endocrinology; Internal medicine; Biology; Medicine; Anatomy; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001922965,0.0004145238,0.0005590917,0.0001842681,0.000469723,0.0001084498,0.000571833,0.0003732833,0.000008113103],"category_scores_gemma":[0.0006223347,0.0002870753,0.0001479573,0.0004253615,0.0008815547,0.00002115835,0.0002506204,0.0004207229,0.000004660455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002820379,"about_ca_system_score_gemma":0.0001613436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009004682,"about_ca_topic_score_gemma":0.0001843514,"domain_scores_codex":[0.9964703,0.0006229493,0.0005971828,0.0007024667,0.0008733702,0.0007337545],"domain_scores_gemma":[0.9979966,0.0003956156,0.0001650284,0.0007718879,0.0004354402,0.0002354207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007285498,0.003045073,0.06528267,0.0002853501,0.0004963251,0.00009265446,0.006840345,0.0008740347,0.8406774,0.005367337,0.004033952,0.06571937],"study_design_scores_gemma":[0.04631214,0.02347053,0.1275918,0.0003343835,0.0003724301,0.00008968738,0.007056586,0.007259879,0.735368,0.006944926,0.04218256,0.003017082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994306,0.002841604,0.000590277,0.0003344209,0.0001025974,0.00127555,0.0002812736,0.000008282555,0.0002600061],"genre_scores_gemma":[0.9805588,0.01843133,0.0002517802,0.0001378023,0.0001001284,0.0001081603,0.00009130934,0.00005897005,0.0002617031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1053094,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04822549616763222,"score_gpt":0.3306338469609756,"score_spread":0.2824083507933434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}