{"id":"W2089526803","doi":"10.1053/j.gastro.2014.12.005","title":"Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid","year":2014,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":565,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc; University of Alberta","funders":"Medical Research Council; European Association for the Study of the Liver; American Association for the Study of Liver Diseases","keywords":"Ursodeoxycholic acid; Obeticholic acid; Placebo; Medicine; Primary biliary cirrhosis; Internal medicine; Gastroenterology; Clinical endpoint; Alkaline phosphatase; Randomized controlled trial; Bile acid; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001931183,0.0006018041,0.002529169,0.0003376422,0.0004130731,0.0004683209,0.0002862066,0.0008505337,0.001631482],"category_scores_gemma":[0.002906439,0.0003802646,0.001149791,0.0003244492,0.0006409391,0.0003577145,0.0002408609,0.0008001057,0.0001945342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592763,"about_ca_system_score_gemma":0.0006664511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003607169,"about_ca_topic_score_gemma":0.0007854339,"domain_scores_codex":[0.9990987,0.0005400545,0.0001220867,0.00007597457,0.00007894848,0.00008431839],"domain_scores_gemma":[0.9978855,0.0009087496,0.0005585858,0.00009047597,0.0001159449,0.0004406716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8277393,0.009679033,0.07428906,0.001799326,0.002600586,0.0004110528,0.0001658184,0.0005739422,0.01356049,0.00007872533,0.0005366784,0.06856601],"study_design_scores_gemma":[0.4813637,0.3658616,0.1434078,0.0001708917,0.002459638,0.0008960378,0.0001098382,0.001327225,0.00260979,0.000131724,0.001624651,0.00003713458],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940429,0.005107796,0.0001034079,0.0001701532,0.00005338883,0.0001722565,0.00005390824,0.00001131466,0.0002847952],"genre_scores_gemma":[0.9983911,0.0008174559,0.0002235024,0.0001686169,0.00009628536,0.0001064371,0.0001028491,0.000001563964,0.00009215475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529169,"threshold_uncertainty_score":0.01021326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00621250841041718,"score_gpt":0.2221132970572849,"score_spread":0.2159007886468677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}