{"id":"W2089585718","doi":"10.1021/ac2026699","title":"Label-Free Solution-Based Kinetic Study of Aptamer–Small Molecule Interactions by Kinetic Capillary Electrophoresis with UV Detection Revealing How Kinetics Control Equilibrium","year":2011,"lang":"en","type":"letter","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Capillary electrophoresis; Aptamer; Chemistry; Kinetics; Biopolymer; Dissociation (chemistry); Molecule; Small molecule; Kinetic energy; Receptor–ligand kinetics; Chromatography; Physical chemistry; Organic chemistry; Polymer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006989601,0.0006324108,0.0005089248,0.000230817,0.0003429559,0.0009692033,0.0007954551,0.001205896,0.001182167],"category_scores_gemma":[0.001056139,0.0002758626,0.0001669268,0.0002408901,0.0009887565,0.001069277,0.0003280863,0.001764881,0.0007549943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001252259,"about_ca_system_score_gemma":0.0003579976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006121615,"about_ca_topic_score_gemma":0.00067905,"domain_scores_codex":[0.9993135,0.0001349007,0.00002879724,0.0001635391,0.0002853389,0.00007397624],"domain_scores_gemma":[0.999217,0.0004320708,0.00009045855,0.00009114698,0.000128143,0.00004121203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009697999,0.00006412798,0.0001936891,0.0001748619,0.000009772165,0.0002421795,0.00008829986,0.000642825,0.9813235,0.005879025,0.001185938,0.01009873],"study_design_scores_gemma":[0.00001797843,0.00005247358,0.0002159112,0.000005762515,0.000005255439,0.0002437802,0.00001529164,0.01823355,0.9745471,0.00096994,0.005668588,0.00002427834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6606894,0.01172892,0.2993301,0.006816069,0.001194847,0.0002440124,0.0005449405,0.001804865,0.01764689],"genre_scores_gemma":[0.9249377,0.002756987,0.06368134,0.001072117,0.0001763192,0.0001690059,0.0001780583,0.0001286106,0.006899793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252259,"threshold_uncertainty_score":0.009085834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131273919713008,"score_gpt":0.2343367688106978,"score_spread":0.2230240296135677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}