{"id":"W2089597096","doi":"10.1139/o05-040","title":"Epigenome programming by Polycomb and Trithorax proteins","year":2005,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenome; Biology; Histone; Epigenetics; Polycomb-group proteins; Transcription (linguistics); DNA methylation; RNA interference; Genetics; Methylation; PRC2; Gene; Transcription factor; Computational biology; Histone H3; RNA; Repressor; Gene expression; Philosophy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002340361,0.0004906002,0.0007273221,0.00004299163,0.0001276509,0.00004523211,0.0002008134,0.001170635,0.00001411209],"category_scores_gemma":[0.00003841275,0.0004311089,0.0001685127,0.00008375161,0.0002331348,0.00000210997,0.0002244664,0.0002481185,0.000004509565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001845095,"about_ca_system_score_gemma":0.0001259202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009395932,"about_ca_topic_score_gemma":0.000001578437,"domain_scores_codex":[0.9980979,0.0001176026,0.0004533863,0.0008702884,0.00006040547,0.000400435],"domain_scores_gemma":[0.9990779,0.0000265808,0.0002842211,0.0003805006,0.00003646265,0.0001943299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000938462,0.00005735016,0.00002042794,0.001899189,0.00005360263,0.000001119612,0.000005032729,2.126684e-8,0.1189171,0.000005703196,0.00008161034,0.8789495],"study_design_scores_gemma":[0.0002191908,0.000220901,7.590383e-7,0.0001836103,0.0001407725,0.000008845594,0.000008297458,5.066893e-7,0.05585096,0.00001173275,0.9428875,0.0004668844],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003452093,0.9946356,0.0001181384,0.00001924701,0.00006441928,0.0005443111,0.0001765489,0.00001655219,0.0009730259],"genre_scores_gemma":[0.00185207,0.9922721,0.0008822343,0.00002240907,0.0004981012,0.0001414286,0.002117105,0.00004927969,0.002165292],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9428059,"threshold_uncertainty_score":0.9998141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684863716142742,"score_gpt":0.2937915139420836,"score_spread":0.2769428767806562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}