{"id":"W2089621615","doi":"10.1182/blood-2012-02-411397","title":"Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Queen's University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"Transcription factor; Gene silencing; Biology; Cell biology; Coactivator; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008033054,0.0002311163,0.0001633855,0.0001050799,0.0003517597,0.0002838141,0.0003029662,0.0002721616,0.001915227],"category_scores_gemma":[0.0001088559,0.0001594393,0.0001369232,0.00008774566,0.0002317269,0.0002195511,0.0001948354,0.000457559,0.0006390261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005733485,"about_ca_system_score_gemma":0.000256345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036007,"about_ca_topic_score_gemma":0.001124421,"domain_scores_codex":[0.9999418,0.00000813393,0.000003007899,0.00001503006,0.00001543042,0.00001661786],"domain_scores_gemma":[0.999934,0.000008605885,0.0000159813,0.000003867636,0.000005341885,0.00003224984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004464168,0.00005784789,0.000396303,0.00004874241,0.000005795122,0.0002036772,0.0000335867,0.000722483,0.9962864,0.0005789102,0.000110606,0.001109216],"study_design_scores_gemma":[0.0001561358,0.0002979189,0.01571191,0.00001694405,0.00001616279,0.0005248372,0.00008855311,0.01349295,0.9645308,0.0008190807,0.004323449,0.00002129232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952981,0.0008892864,0.002032494,0.0001329563,0.00001075753,0.00002032892,0.0001428494,0.00007340043,0.001399854],"genre_scores_gemma":[0.9977745,0.0001906015,0.0008490639,0.00003209263,0.000003271211,0.000008143196,0.0002458544,0.000008043882,0.000888358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915227,"threshold_uncertainty_score":0.006407022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05828934107921162,"score_gpt":0.3263323527270245,"score_spread":0.2680430116478129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}