{"id":"W2089637490","doi":"10.1016/j.tox.2004.12.019","title":"Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity","year":2005,"lang":"en","type":"review","venue":"Toxicology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canada Research Chairs","keywords":"Hapten; Mechanism (biology); Drug; Sensitization; Drug metabolism; Metabolite; Drug allergy; Reactive oxygen species; Immunology; Pharmacology; Chemistry; Antigen; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005373873,0.0002311123,0.002009443,0.0001676045,0.0000610115,0.000003512582,0.00008261003,0.000220804,0.000005653659],"category_scores_gemma":[0.0002534116,0.000157947,0.0003510746,0.0002129811,0.0003428799,0.00004860419,0.00005308494,0.0002641898,0.000003760231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006758437,"about_ca_system_score_gemma":0.0002482922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007450772,"about_ca_topic_score_gemma":0.00009047671,"domain_scores_codex":[0.9985729,0.0002575233,0.0005628855,0.0002733389,0.0001321306,0.0002012128],"domain_scores_gemma":[0.9979845,0.0008803213,0.0006019312,0.0003323418,0.000145996,0.00005496004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002403002,0.0001032044,8.795648e-7,0.002895351,0.0002066746,0.000001361141,0.000450289,0.00001906032,0.000118374,0.00329788,0.00003029711,0.9928526],"study_design_scores_gemma":[0.001395482,0.000009430216,0.00003309814,0.001463247,0.002676541,0.0001988201,0.0002186261,0.0003855735,0.0001318271,0.00009130484,0.9932774,0.0001186989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002348135,0.9912468,0.0002770769,0.0002211402,0.0002405749,0.001809593,0.00006723135,0.00002480637,0.005877923],"genre_scores_gemma":[0.01628274,0.9820933,0.0004825875,0.0001398352,0.0003577468,0.0001183145,0.00004693591,0.00004493854,0.0004336245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993247,"threshold_uncertainty_score":0.644089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02627107165838182,"score_gpt":0.3262766133134737,"score_spread":0.3000055416550919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}