{"id":"W2089642386","doi":"10.1074/jbc.m408679200","title":"Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell Fate","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Terry Fox Foundation; Great Ormond Street Hospital Charity","keywords":"Transactivation; Chromatin immunoprecipitation; Transcription factor; POU domain; Biology; Cell fate determination; Cell biology; Molecular biology; Mutant; Electrophoretic mobility shift assay; Embryonic stem cell; Promoter; Gene; Gene expression; Genetics; Homeobox","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":{"nature":"Correction","reason":"Error in Image;Investigation by Company/Institution;","date":"1/9/2015 0:00","openalex_flagged":false},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077674,0.0003193223,0.0002965765,0.0003786711,0.0001834297,0.0002404156,0.0003034611,0.000264501,0.001774178],"category_scores_gemma":[0.0001866279,0.0002111756,0.0003088044,0.0001812044,0.0002744131,0.0002103132,0.0001515661,0.001047468,0.0004499461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000406182,"about_ca_system_score_gemma":0.0002424889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008452184,"about_ca_topic_score_gemma":0.0013714,"domain_scores_codex":[0.999652,0.00009057582,0.00004329201,0.00005812008,0.00007955104,0.00007636099],"domain_scores_gemma":[0.9997283,0.00008331035,0.00005747781,0.00003689703,0.00002488207,0.00006911752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001164147,0.00005899457,0.00005063669,0.00001619125,0.000003245119,0.00001703185,0.00001043548,0.00003646372,0.9993114,0.00007399774,0.00001746171,0.000287757],"study_design_scores_gemma":[0.00002236195,0.0003389377,0.001261254,0.000004807706,0.000007657661,0.00008799288,0.0000128168,0.0009185344,0.9964191,0.00003918784,0.0008852104,0.000002330411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906474,0.002821838,0.004256458,0.0001721061,0.00008030955,0.00004536084,0.0005698468,0.00009975194,0.001306966],"genre_scores_gemma":[0.9915559,0.001224999,0.003157079,0.00006259738,0.00001455929,0.00008305611,0.001026919,0.0000413269,0.002833505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774178,"threshold_uncertainty_score":0.005935252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913471580663513,"score_gpt":0.2344409272567668,"score_spread":0.2153062114501317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}