{"id":"W2089657261","doi":"10.1002/glia.20185","title":"Activation of catechol‐O‐methyltransferase in astrocytes stimulates homocysteine synthesis and export to neurons","year":2005,"lang":"en","type":"article","venue":"Glia","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Catechol-O-methyl transferase; Neurodegeneration; Biology; Astrocyte; Biochemistry; Extracellular; Glutathione; Endocrinology; Internal medicine; Enzyme; Medicine; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008111277,0.0002191339,0.0002556191,0.00008848887,0.00011891,0.0002035667,0.00007938618,0.0001648803,0.0004637849],"category_scores_gemma":[0.0001068366,0.0001082472,0.0002228445,0.00008947203,0.0001259639,0.0001213208,0.0001483277,0.000207455,0.0002447858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096571,"about_ca_system_score_gemma":0.0001701301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312308,"about_ca_topic_score_gemma":0.002605113,"domain_scores_codex":[0.9999306,0.00001268245,0.000006968198,0.00001304785,0.00001701925,0.00001963609],"domain_scores_gemma":[0.9999256,0.00001651109,0.0000132467,0.00001226862,0.00001460351,0.00001775745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001470845,0.000008115048,0.0001770657,0.00001788894,0.000002843943,0.00007944853,0.00001558698,0.00001094312,0.9989744,0.00001927226,0.000008942539,0.0005383511],"study_design_scores_gemma":[0.00003133273,0.0003078262,0.008207544,0.000006346439,0.00001617941,0.0002414948,0.00005901701,0.000420173,0.9896299,0.00005056713,0.001026896,0.000002652519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996516,0.001140654,0.001076385,0.00004829445,0.00001506145,0.0000101985,0.00009200141,0.0000270598,0.001074398],"genre_scores_gemma":[0.995619,0.00114267,0.001489878,0.00002576922,0.000008240452,0.00001906492,0.0001678641,0.00001105485,0.00151664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312308,"threshold_uncertainty_score":0.002609372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175822226486997,"score_gpt":0.3008961261809207,"score_spread":0.2791379039160508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}