{"id":"W2089671884","doi":"10.1007/s00424-006-0115-0","title":"Preface: the concept and consequences of multidrug resistance","year":2006,"lang":"en","type":"review","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC; National Cancer Institute; Genome Canada","keywords":"Multiple drug resistance; ATP-binding cassette transporter; Transporter; Computational biology; P-glycoprotein; Context (archaeology); Biology; Gene; Identification (biology); Homology (biology); Bioinformatics; Genetics; Drug resistance; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007255372,0.0003640359,0.002041464,0.000163046,0.00009051095,0.000009807967,0.0004287357,0.00006337246,0.00002382588],"category_scores_gemma":[0.00005789384,0.0001907253,0.0006300979,0.0001480745,0.001501483,0.00004118102,0.00004802717,0.0007890268,0.000005397751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002189186,"about_ca_system_score_gemma":0.0002946537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003971327,"about_ca_topic_score_gemma":0.00000303655,"domain_scores_codex":[0.996879,0.0009976744,0.001293585,0.0002802815,0.000263554,0.000285935],"domain_scores_gemma":[0.9973845,0.0003509787,0.001659355,0.0003520369,0.0001229907,0.0001301261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001636055,0.000714693,0.0000263169,0.04913118,0.003822775,0.002930597,0.004718277,0.0000388382,0.04514145,0.004521116,0.01506689,0.8722518],"study_design_scores_gemma":[0.0009003446,0.0003701379,0.0004937963,0.01240969,0.001448125,0.000371982,0.0001264346,6.245856e-7,0.0002808693,0.0003619398,0.9830041,0.0002319706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009227291,0.9944414,0.00009432825,0.0001888972,0.000292994,0.0003819645,0.00006427606,0.000009899154,0.003603509],"genre_scores_gemma":[0.006525001,0.9904656,0.001252249,0.00006153256,0.0003881437,0.000002004184,0.00003294123,0.0000593035,0.001213205],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9679372,"threshold_uncertainty_score":0.7777553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857187425924956,"score_gpt":0.2919634396467187,"score_spread":0.2633915653874691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}