{"id":"W2089686819","doi":"10.1016/j.celrep.2014.02.045","title":"Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"KRAS; ERBB3; Kinome; Downregulation and upregulation; Cancer research; Receptor tyrosine kinase; Mutant; Cetuximab; ErbB; MEK inhibitor; Kinase; Colorectal cancer; Biology; Cancer; MAPK/ERK pathway; Signal transduction; Medicine; Cell biology; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001569323,0.00007767211,0.0001107578,0.00003124146,0.00002516856,0.000005303644,0.00001674688,0.00009079756,0.00001023378],"category_scores_gemma":[0.00003410044,0.00007826483,0.00002432881,0.00006943805,0.00003184407,0.0000053703,0.00001745738,0.00004772084,3.641458e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001843781,"about_ca_system_score_gemma":0.00004803202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006830391,"about_ca_topic_score_gemma":0.000423163,"domain_scores_codex":[0.99928,0.00003058646,0.0002391612,0.0002536892,0.00008944662,0.0001071552],"domain_scores_gemma":[0.9996529,0.000004233189,0.0001048375,0.0001436704,0.00005594404,0.00003839619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000061605,0.00003125033,0.002645911,0.00006795828,0.000004338423,0.0000217069,0.0001694433,0.00003424849,0.9958029,0.0001741891,0.0005601171,0.0004263218],"study_design_scores_gemma":[0.0002401362,0.00009434978,0.01177584,0.0000498618,0.000009516182,0.00003427793,0.00002695855,0.00000434431,0.9600799,0.000417798,0.02717043,0.0000966038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959851,0.0006700382,0.0008932212,0.000116534,0.0002277565,0.0001707503,0.00000594117,0.000004310491,0.001926361],"genre_scores_gemma":[0.9989551,0.0001333239,0.0003175196,0.00009744613,0.0001103934,0.00003291359,0.00004140098,0.000008417957,0.0003035049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03572303,"threshold_uncertainty_score":0.3191547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008725670807022873,"score_gpt":0.2299171364603361,"score_spread":0.2211914656533132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}