{"id":"W2089736373","doi":"10.1016/j.biocel.2014.03.004","title":"H2A-DUBbing the mammalian epigenome: Expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology","year":2014,"lang":"en","type":"review","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Deubiquitinating enzyme; Epigenome; Ubiquitin; Biology; Histone; Chromatin; Histone H2A; Cell biology; Chromatin remodeling; Histone-modifying enzymes; Epigenomics; Genetics; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001549548,0.0004957701,0.001081149,0.0001664583,0.0001634267,0.00004641288,0.001643513,0.0006740394,0.0000250361],"category_scores_gemma":[0.0003336604,0.0003134783,0.0005371775,0.00009252422,0.0004795321,0.000006727235,0.0004648092,0.0006483267,0.000002823605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388343,"about_ca_system_score_gemma":0.0003312207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001768773,"about_ca_topic_score_gemma":0.000004334441,"domain_scores_codex":[0.9972487,0.0004224645,0.001154692,0.0005492537,0.0001317506,0.0004931134],"domain_scores_gemma":[0.9971486,0.0004060146,0.001705989,0.0003849923,0.0002563486,0.00009811079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003054295,0.0001014272,0.00008492162,0.00205233,0.0005335014,0.00001087603,0.0001967323,0.00001190039,0.7616464,0.0002210255,0.001639351,0.233196],"study_design_scores_gemma":[0.0007849998,0.0003234097,0.000002500792,0.0004594892,0.0001740569,0.0001469754,0.0001947704,0.00001800892,0.2906811,0.0004307531,0.7064196,0.0003643054],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02566702,0.9707062,0.0008942151,0.000327393,0.001165778,0.0004564954,0.0001670571,0.000006388768,0.0006094647],"genre_scores_gemma":[0.1594277,0.8349775,0.001109461,0.0003833476,0.002804251,0.0001064239,0.0005917584,0.00007163972,0.000527966],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7047803,"threshold_uncertainty_score":0.9999318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907200327971737,"score_gpt":0.3193396120278205,"score_spread":0.3002676087481031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}