{"id":"W2089738694","doi":"10.1139/y06-072","title":"Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na<sup>+</sup>/H<sup>+</sup>exchanger-1 (NHE-1) inhibitionThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Calcineurin; NFAT; Internal medicine; Endocrinology; Muscle hypertrophy; Left ventricular hypertrophy; Sodium–hydrogen antiporter; Brain natriuretic peptide; Medicine; Myocyte; Blood pressure; Chemistry; Heart failure; Sodium","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698361,0.0004224005,0.0005056797,0.0002543828,0.0001899045,0.0003591709,0.000258108,0.0002614262,0.002770177],"category_scores_gemma":[0.0001035247,0.0001933051,0.0002984403,0.0001124947,0.0003151492,0.0002927525,0.0002399496,0.001377802,0.0004473775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198664,"about_ca_system_score_gemma":0.0002897799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004263284,"about_ca_topic_score_gemma":0.001048744,"domain_scores_codex":[0.9998666,0.00001318897,0.00001046136,0.00002407055,0.00003676237,0.00004891145],"domain_scores_gemma":[0.999856,0.000007417012,0.00004727572,0.00001143471,0.00001421558,0.0000635775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000466531,0.0001045248,0.0003997503,0.00003914741,0.00001173236,0.00007830763,0.00001322831,0.000008449581,0.9960568,0.00006246212,0.00008788359,0.002671196],"study_design_scores_gemma":[0.0001068148,0.001731845,0.06420459,0.00001873388,0.000103109,0.0008935127,0.0001216571,0.0007926271,0.9284695,0.0001633301,0.003381646,0.00001248832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898294,0.005197837,0.002276604,0.000301991,0.0001496995,0.00003404966,0.0002410453,0.0002261933,0.00174318],"genre_scores_gemma":[0.9906013,0.002944818,0.001008221,0.0001088917,0.00008259419,0.00004732575,0.0003473567,0.00003195759,0.004827609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002770177,"threshold_uncertainty_score":0.009267211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008684616841299684,"score_gpt":0.2100882460085922,"score_spread":0.2014036291672925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}