{"id":"W2089749592","doi":"10.1371/journal.pone.0072113","title":"PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences; Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Proprotein Convertases; PCSK9; Furin; Kexin; LDL receptor; Proprotein convertase; Zymogen; Biochemistry; Protein precursor; Proteases; Chemistry; Enzyme; Cell biology; Biology; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422904,0.0003399502,0.0004150979,0.0001959172,0.0001164677,0.0003412175,0.0003610073,0.0003437046,0.001019053],"category_scores_gemma":[0.00007012897,0.000171223,0.0003719424,0.0002285668,0.0001634426,0.0001817682,0.0001325223,0.0008455458,0.0004074113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004569087,"about_ca_system_score_gemma":0.0002353511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005368474,"about_ca_topic_score_gemma":0.0006945354,"domain_scores_codex":[0.9998832,0.00001353703,0.00001234714,0.00002382807,0.00003710839,0.00002992246],"domain_scores_gemma":[0.9999604,0.000005663934,0.00001058634,0.000005314297,0.000006344975,0.00001167894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000480107,0.0001234049,0.00006824263,0.00007524485,0.00003021768,0.00008933817,0.0000153489,0.0003316085,0.9942207,0.0002800254,0.0002033462,0.004082392],"study_design_scores_gemma":[0.0001705703,0.0006595344,0.001000024,0.00000678833,0.00005538463,0.0004354023,0.0000110551,0.001987173,0.9869436,0.00006117007,0.00865875,0.00001048564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772274,0.009647122,0.00781199,0.0003121287,0.0001646893,0.0001517887,0.001016141,0.000428718,0.003240051],"genre_scores_gemma":[0.9830011,0.004472543,0.005016366,0.0001163881,0.00002033969,0.00009719721,0.001776566,0.00005310888,0.005446335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019053,"threshold_uncertainty_score":0.003409088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431556645049198,"score_gpt":0.2328127475302089,"score_spread":0.198497181079717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}