{"id":"W2089762402","doi":"10.1038/ni.2685","title":"Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells","year":2013,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Cancer Research UK","keywords":"Signal transducing adaptor protein; breakpoint cluster region; Cell biology; Protein kinase B; Signal transduction; B-cell receptor; Phosphorylation; Tyrosine kinase; Cancer research; Chemistry; Biology; B cell; Receptor; Antibody; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715947,0.0002975165,0.0002199876,0.0004198528,0.0007118888,0.0009555434,0.0003913114,0.0003724802,0.002878785],"category_scores_gemma":[0.0003142369,0.000283352,0.000339873,0.0003029153,0.0002972469,0.0007476225,0.0005481665,0.001384997,0.001610528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00182834,"about_ca_system_score_gemma":0.000934146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00370589,"about_ca_topic_score_gemma":0.005973726,"domain_scores_codex":[0.9995533,0.0000437605,0.00002849943,0.0000759469,0.0001516746,0.0001468337],"domain_scores_gemma":[0.99979,0.00002031688,0.00003980353,0.00002639037,0.00005255329,0.00007094975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004295547,0.00006594684,0.0006816468,0.00007568799,0.000008983316,0.00007159587,0.00002687722,0.0001940247,0.9938189,0.0006852744,0.0005424967,0.003398888],"study_design_scores_gemma":[0.00007041795,0.0000954337,0.03848966,0.00001957791,0.00002118005,0.0003628847,0.0001005974,0.004398537,0.9480509,0.0004939787,0.007877085,0.00001975156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796531,0.004830617,0.003670522,0.0008281876,0.0001751345,0.0000521562,0.001568857,0.0002314566,0.00898987],"genre_scores_gemma":[0.9884816,0.001299813,0.002090402,0.000125956,0.00002841277,0.00005270413,0.001116062,0.00004730991,0.006757732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00370589,"threshold_uncertainty_score":0.01326561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109725285037,"score_gpt":0.2261244465306027,"score_spread":0.2150271936802327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}