{"id":"W2089762402","doi":"10.1038/ni.2685","title":"Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells","year":2013,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Cancer Research UK","keywords":"Signal transducing adaptor protein; breakpoint cluster region; Cell biology; Protein kinase B; Signal transduction; B-cell receptor; Phosphorylation; Tyrosine kinase; Cancer research; Chemistry; Biology; B cell; Receptor; Antibody; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0006049008,0.0004251559,0.0006688911,0.0002923878,0.0002689966,0.00002179957,0.001462889,0.001647207,0.001417971],"category_scores_gemma":[0.0002626684,0.0002374639,0.0001888582,0.0006598271,0.0008734128,0.00009409993,0.0005025453,0.002345134,0.00390169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009508102,"about_ca_system_score_gemma":0.0001253464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000811674,"about_ca_topic_score_gemma":0.0003069487,"domain_scores_codex":[0.9966573,0.0009609938,0.0007865632,0.0005694877,0.00007893085,0.000946731],"domain_scores_gemma":[0.9971844,0.0009917486,0.0003235624,0.001252449,0.0002215947,0.00002625929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002155016,0.0002525504,0.0002228557,0.000009273369,0.0003168458,0.000005878788,0.001249884,0.000012111,0.9736758,0.002174292,0.01375309,0.008111864],"study_design_scores_gemma":[0.001225166,0.0004188513,0.005832635,0.00003197069,0.00002148012,0.00005207124,0.0008351722,0.000002291176,0.6748745,0.000573029,0.3159043,0.0002284755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449066,0.03452438,0.000008155515,0.01273887,0.003936931,0.002160865,0.00004558971,0.00009715177,0.001581466],"genre_scores_gemma":[0.9907942,0.0004532681,0.00005833808,0.001909598,0.00005680749,0.0004656945,0.0001107595,0.00003813497,0.006113188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3021512,"threshold_uncertainty_score":0.9999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109725285037,"score_gpt":0.2261244465306027,"score_spread":0.2150271936802327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}