{"id":"W2089815674","doi":"10.1002/aur.24","title":"<i>MECP2</i> promoter methylation and X chromosome inactivation in autism","year":2008,"lang":"en","type":"article","venue":"Autism Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Mental Health; National Institutes of Health","keywords":"Autism; MECP2; X-inactivation; Genetics; Methylation; Heritability of autism; DNA methylation; Chromosome; Biology; Psychology; X chromosome; Developmental psychology; Gene; Autism spectrum disorder; Phenotype; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003297666,0.00008723643,0.00007883827,0.0001303654,0.0001389873,0.00001602888,0.00009608212,0.0001105224,0.00001555691],"category_scores_gemma":[0.00005568427,0.00008945813,0.00001691302,0.0002241121,0.00013246,0.000007250243,0.0001548169,0.0001662966,0.00001358695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002144416,"about_ca_system_score_gemma":0.00008656426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007540629,"about_ca_topic_score_gemma":0.00004746412,"domain_scores_codex":[0.9988963,0.0001266934,0.0001379936,0.0003241552,0.0002341494,0.0002807361],"domain_scores_gemma":[0.9997101,0.00001592682,0.00002106318,0.0001647027,0.00002842983,0.00005975462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002478325,0.00005692273,0.004826561,0.00001163485,0.00000648764,0.00001205152,0.0002264961,0.000005720629,0.989448,0.0002658416,0.0004533023,0.004662205],"study_design_scores_gemma":[0.0006617664,0.0002650271,0.7930998,0.00001300715,0.000001105104,0.00003347363,0.00004002568,0.0001171533,0.1947958,0.001640814,0.009175655,0.000156335],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964778,0.0004331612,0.00007880548,0.00107826,0.00003963514,0.000263743,0.000002487437,0.000005904835,0.001620214],"genre_scores_gemma":[0.9975502,0.001185458,0.0003202272,0.00008194805,0.000008731949,0.0000391446,0.00004593642,0.00001594075,0.0007523359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7946522,"threshold_uncertainty_score":0.3647997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365308413149861,"score_gpt":0.3170857971326336,"score_spread":0.273432713001135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}