{"id":"W2089825206","doi":"10.1161/circulationaha.108.787390","title":"Novel Small Interfering RNA–Containing Solution Protecting Donor Organs in Heart Transplantation","year":2009,"lang":"en","type":"article","venue":"Circulation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Transplantation; Small interfering RNA; Medicine; Reperfusion injury; Viaspan; Ischemia; Tumor necrosis factor alpha; Gene expression; Cold storage; RNA interference; RNA; Immunology; Surgery; Gene; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832729,0.0005113169,0.0003148844,0.0002743131,0.0001900181,0.0003102775,0.000424159,0.0006040383,0.0008722616],"category_scores_gemma":[0.000183715,0.0001459874,0.0003033101,0.000126876,0.0002173893,0.000333912,0.0002106429,0.0003836089,0.000319797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894611,"about_ca_system_score_gemma":0.0002389029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001508102,"about_ca_topic_score_gemma":0.0002642812,"domain_scores_codex":[0.9998678,0.00002468543,0.00001515433,0.00003014268,0.00004584272,0.00001636138],"domain_scores_gemma":[0.9998972,0.00002568521,0.00003723842,0.000007023661,0.00001705826,0.00001584699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000571611,0.00003316488,0.00004334774,0.0001158201,0.000007115629,0.00004633398,0.000009106003,0.0001024744,0.9944786,0.000154302,0.00007951761,0.004873089],"study_design_scores_gemma":[0.00003530744,0.0006805541,0.0004335215,0.00001363009,0.00003708061,0.0003141053,0.000008143316,0.001117356,0.9933648,0.00007282791,0.003913944,0.000008700036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8986064,0.02243589,0.07144215,0.0005031269,0.0005689297,0.0005393033,0.0003598374,0.0007052568,0.004839187],"genre_scores_gemma":[0.9235677,0.008615569,0.06132698,0.0004100413,0.0001393623,0.0005812595,0.0005253188,0.0000828823,0.004750956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008722616,"threshold_uncertainty_score":0.002918005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02431402807410481,"score_gpt":0.2492263666783089,"score_spread":0.2249123386042041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}