{"id":"W2089825206","doi":"10.1161/circulationaha.108.787390","title":"Novel Small Interfering RNA–Containing Solution Protecting Donor Organs in Heart Transplantation","year":2009,"lang":"en","type":"article","venue":"Circulation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Transplantation; Small interfering RNA; Medicine; Reperfusion injury; Viaspan; Ischemia; Tumor necrosis factor alpha; Gene expression; Cold storage; RNA interference; RNA; Immunology; Surgery; Gene; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180679,0.00009009134,0.00007916481,0.00007001666,0.00006383283,0.00002462509,0.00005707008,0.0000995919,0.000004107273],"category_scores_gemma":[0.00003476957,0.0001027168,0.00003959303,0.00008381221,0.000008355371,0.00001269054,0.000007960059,0.00009483811,0.000004676963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003425844,"about_ca_system_score_gemma":0.00002475184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000631697,"about_ca_topic_score_gemma":0.0001496177,"domain_scores_codex":[0.9993541,0.0000294544,0.0001865748,0.0002261487,0.00005211732,0.0001516398],"domain_scores_gemma":[0.9997686,0.000005194867,0.00005149365,0.0001068828,0.00004360229,0.00002420598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000752322,0.00002841979,0.006460161,0.000008938469,0.000004167525,8.968905e-7,0.0003067397,0.003023128,0.9849393,0.00001509993,0.000002802164,0.005135049],"study_design_scores_gemma":[0.0007420254,0.0002706746,0.3048146,0.000103284,0.000009699761,0.00003879094,0.0001637944,0.006495666,0.6870233,0.0000624793,0.00006579277,0.0002098604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.885263,0.00006922985,0.1140658,0.0001159125,0.00007060221,0.0001672952,0.000001254321,0.00001510327,0.0002318494],"genre_scores_gemma":[0.9987757,0.0000104177,0.0008471081,0.0001444818,0.0001230239,0.00001126426,0.00006913992,0.000008303788,0.00001057573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2983544,"threshold_uncertainty_score":0.418867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02431402807410481,"score_gpt":0.2492263666783089,"score_spread":0.2249123386042041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}