{"id":"W2089830667","doi":"10.1167/iovs.06-1465","title":"Coexpression and Interaction of Wild-type and Missense RS1 Mutants Associated with X-Linked Retinoschisis: Its Relevance to Gene Therapy","year":2007,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute","keywords":"Mutant; Biology; Wild type; Molecular biology; Retinoschisis; Cell biology; Protein subunit; Missense mutation; Secretion; Mutant protein; Gene; Mutation; Genetics; Retinal; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965101,0.0003168405,0.0002368382,0.0001754619,0.0001626942,0.000264058,0.0002376838,0.0002730646,0.0007240563],"category_scores_gemma":[0.0001247525,0.0001040851,0.0002635819,0.0001449823,0.0002490278,0.0001567003,0.000168092,0.0003762881,0.0003388269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003661671,"about_ca_system_score_gemma":0.0001482002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003548503,"about_ca_topic_score_gemma":0.0004419159,"domain_scores_codex":[0.9997973,0.00003697176,0.00003239162,0.00004301501,0.00006243742,0.00002788519],"domain_scores_gemma":[0.9998724,0.00002942713,0.00004190543,0.00002114697,0.000008870496,0.00002615292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000618811,0.00002526813,0.0001647733,0.00001367398,0.000003490487,0.00003206839,0.000008660245,0.00003350866,0.9992673,0.00003490598,0.0000127603,0.0003418825],"study_design_scores_gemma":[0.00001471708,0.0002421886,0.002976495,0.000003116764,0.00002028749,0.0003830093,0.00001347674,0.0006118841,0.9946126,0.000009303732,0.001110288,0.00000269717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983222,0.0005108665,0.0006318639,0.00004316129,0.00001000717,0.00001180568,0.00009719675,0.00001795019,0.0003550207],"genre_scores_gemma":[0.9967073,0.0004462046,0.001447004,0.00002051108,0.000005758937,0.0000215288,0.0004160026,0.00001476322,0.0009209889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007240563,"threshold_uncertainty_score":0.002656758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043313806147156,"score_gpt":0.3320688270809992,"score_spread":0.3016356890195276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}