{"id":"W2089943657","doi":"10.1016/j.phymed.2013.06.001","title":"Berberine's effect on periodontal tissue degradation by matrix metalloproteinases: an in vitro and in vivo experiment","year":2013,"lang":"en","type":"article","venue":"Phytomedicine","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministère de la Défense Nationale","keywords":"Berberine; Matrix metalloproteinase; In vivo; Chemistry; Matrix metalloproteinase inhibitor; Periodontitis; Porphyromonas gingivalis; Dental alveolus; Lipopolysaccharide; Pharmacology; Medicine; Internal medicine; Dentistry; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007914132,0.0007974067,0.0006513859,0.0004142901,0.0004751619,0.0002560262,0.0003391687,0.000623618,0.00252538],"category_scores_gemma":[0.0004106291,0.000417238,0.0008499495,0.0003496025,0.0006304288,0.0006340067,0.0002284638,0.001043332,0.0003114218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109009,"about_ca_system_score_gemma":0.0003337688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151456,"about_ca_topic_score_gemma":0.001649514,"domain_scores_codex":[0.9995978,0.0001242267,0.0000380584,0.00007870438,0.00005080402,0.0001104078],"domain_scores_gemma":[0.9995321,0.0002095573,0.00006709139,0.0000690583,0.00004519832,0.00007700499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007558549,0.001023798,0.0003092765,0.0001815173,0.00002524355,0.0001871888,0.0001167398,0.00009318864,0.9877693,0.0000676179,0.00004783596,0.002619796],"study_design_scores_gemma":[0.000324926,0.01239865,0.004895186,0.00000945049,0.000119998,0.0002929809,0.00008490141,0.0003845473,0.980386,0.00004797785,0.001040532,0.00001489611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993751,0.003374734,0.001410471,0.00009579227,0.00006167468,0.00008119998,0.0001382135,0.00003217332,0.001054723],"genre_scores_gemma":[0.9905628,0.002371927,0.002679897,0.00005718761,0.00007961618,0.00008248683,0.000205367,0.00001213659,0.003948587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00252538,"threshold_uncertainty_score":0.008448243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145847346108197,"score_gpt":0.3250597271630109,"score_spread":0.3136012537019289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}