{"id":"W2089947577","doi":"10.1080/00498250310001638460","title":"Effects of renal diseases on the regulation and expression of renal and hepatic drug-metabolizing enzymes: a review","year":2004,"lang":"en","type":"review","venue":"Xenobiotica","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Kidney; Intracellular; Biology; Enzyme; Chemistry; Pharmacology; Endocrinology; Internal medicine; Medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007993263,0.000488316,0.001750098,0.0001671319,0.0001692985,0.00001358297,0.000292372,0.0003074048,0.0001431957],"category_scores_gemma":[0.0003848133,0.0003087877,0.0003086023,0.0002927626,0.0004280127,0.00004638326,0.0001974846,0.0007018844,0.0000078168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002688235,"about_ca_system_score_gemma":0.0002092544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003941137,"about_ca_topic_score_gemma":2.887252e-7,"domain_scores_codex":[0.9965225,0.00153834,0.0008919889,0.0004559984,0.0002751386,0.0003160707],"domain_scores_gemma":[0.9963528,0.002183428,0.0008141334,0.0003376395,0.00008636236,0.0002256639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001461038,0.0006130779,0.00001287919,0.2968366,0.0007230772,0.00002274592,0.0003148122,0.00001956243,0.01033157,0.004864736,0.002202352,0.6839125],"study_design_scores_gemma":[0.001094632,0.00009730187,0.00009674031,0.09081885,0.01045703,0.00002576401,0.00000533018,0.00004936532,0.03415045,0.0005426072,0.8622134,0.000448547],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008641682,0.9964849,0.00001042728,0.000135472,0.0002940747,0.001792663,0.0001617452,0.00002005254,0.0002364833],"genre_scores_gemma":[0.007335128,0.9917986,0.000073512,0.0003704424,0.000176972,0.0000835653,0.00004165524,0.00004516221,0.00007491196],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.860011,"threshold_uncertainty_score":0.9999364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06439543471889159,"score_gpt":0.4096500033973932,"score_spread":0.3452545686785016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}