{"id":"W2089963166","doi":"10.1139/o04-116","title":"Order or chaos? An evaluation of the regulation of protein kinase CK2","year":2004,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Biology; Cell biology; Kinase; Function (biology); Casein kinase 2; Phosphorylation; Population; Protein kinase A; Cellular compartment; Protein subunit; Serine; Cellular model; Computational biology; Cell; Genetics; Gene; Cyclin-dependent kinase 2; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005583811,0.0002847647,0.0005212603,0.00003961655,0.00006411879,0.000006515515,0.0002389454,0.0007415051,0.00009606378],"category_scores_gemma":[0.0001580489,0.0001855788,0.0001847631,0.0001881397,0.0002656315,0.00000306691,0.00012523,0.0001226768,9.101996e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003075925,"about_ca_system_score_gemma":0.0009062871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009639558,"about_ca_topic_score_gemma":0.000003312696,"domain_scores_codex":[0.9983719,0.0003112704,0.0005235246,0.0004644618,0.000164055,0.0001648023],"domain_scores_gemma":[0.9983871,0.00001075119,0.0006717269,0.0005860133,0.0002848279,0.00005957092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005651637,0.0001142726,0.00000415838,0.007757065,0.0000594738,2.174922e-7,0.00001144742,0.00001842469,0.7521969,0.00008642439,0.000009941084,0.2396851],"study_design_scores_gemma":[0.0005939707,0.0001994993,0.000006265808,0.002161019,0.0003750112,0.00001475933,0.00001615738,0.00002924657,0.8689497,0.0001682724,0.127207,0.0002791693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02873916,0.9697535,0.00006494547,0.000008601481,0.00006238224,0.000983165,0.00009272152,0.000005874217,0.0002896465],"genre_scores_gemma":[0.248393,0.7474494,0.0006642814,0.00001728593,0.0003469513,0.0002523451,0.001953956,0.00005440633,0.0008684104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.239406,"threshold_uncertainty_score":0.7567683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0344476586782258,"score_gpt":0.3106715613953045,"score_spread":0.2762239027170787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}