{"id":"W2089986126","doi":"10.1021/tx800335p","title":"Arsenite and its Mono- and Dimethylated Trivalent Metabolites Enhance the Formation of Benzo[<i>a</i>]pyrene Diol Epoxide−DNA Adducts in Xeroderma Pigmentosum Complementation Group A Cells","year":2009,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"Xeroderma pigmentosum; Benzo(a)pyrene; Chemistry; Carcinogen; DNA; Nucleotide excision repair; Arsenite; Adduct; Biochemistry; DNA damage; DNA adduct; Glutathione; DNA repair; Complementation; Pyrene; Arsenic; Enzyme; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106383,0.0005272801,0.0003768369,0.0004837663,0.0001716432,0.0003454353,0.0002494834,0.0004442707,0.001442474],"category_scores_gemma":[0.0001709407,0.000267619,0.0003354074,0.0002448637,0.0001717806,0.0001799417,0.0002735122,0.0003576356,0.0003993124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256645,"about_ca_system_score_gemma":0.0001664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001434225,"about_ca_topic_score_gemma":0.00150649,"domain_scores_codex":[0.9997235,0.00005965193,0.00004802602,0.00003961639,0.00008921129,0.00003998903],"domain_scores_gemma":[0.9997615,0.00003661566,0.0000611963,0.00004203157,0.00004163955,0.00005705504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008497031,0.0000258401,0.0001275174,0.00001117857,0.000005258188,0.00002254237,0.00001099927,0.00002178361,0.999397,0.000007940483,0.00001173645,0.0002732716],"study_design_scores_gemma":[0.00001835706,0.0008166091,0.005343609,0.000002673868,0.00001749302,0.0001674493,0.00004241254,0.0004276567,0.9921216,0.00001920141,0.001017657,0.000005251226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977653,0.0006036105,0.0007469242,0.00004946857,0.00001531191,0.00002126203,0.0001865547,0.00007462219,0.0005369544],"genre_scores_gemma":[0.9941332,0.0003873965,0.001235832,0.00004036282,0.000006512931,0.00002633025,0.0004731365,0.00002063357,0.003676692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442474,"threshold_uncertainty_score":0.004825532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04426219727895934,"score_gpt":0.3473413482200487,"score_spread":0.3030791509410893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}