{"id":"W2089986126","doi":"10.1021/tx800335p","title":"Arsenite and its Mono- and Dimethylated Trivalent Metabolites Enhance the Formation of Benzo[<i>a</i>]pyrene Diol Epoxide−DNA Adducts in Xeroderma Pigmentosum Complementation Group A Cells","year":2009,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Arsenic contamination and mitigation","field":"Environmental Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"Xeroderma pigmentosum; Benzo(a)pyrene; Chemistry; Carcinogen; DNA; Nucleotide excision repair; Arsenite; Adduct; Biochemistry; DNA damage; DNA adduct; Glutathione; DNA repair; Complementation; Pyrene; Arsenic; Enzyme; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001058068,0.0000946201,0.0001666596,0.0001164978,0.00006887518,0.00001276629,0.0001273941,0.00008204783,0.0001228084],"category_scores_gemma":[0.0001787896,0.00007912199,0.00001675441,0.0003601449,0.0002310723,0.0002265222,0.0001848693,0.0002059415,0.00001023902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002209454,"about_ca_system_score_gemma":0.000009164832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004390735,"about_ca_topic_score_gemma":0.0002256778,"domain_scores_codex":[0.9984433,0.0003297431,0.0003736314,0.0002625939,0.0002778959,0.0003128298],"domain_scores_gemma":[0.9992718,0.0004185661,0.00009395774,0.0001131716,0.00002392179,0.00007865878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000635041,0.0001011336,0.0005471601,0.00001550608,0.000001918576,0.000001969698,0.001010858,0.00001009514,0.9736882,0.0004760125,0.00005406388,0.02402957],"study_design_scores_gemma":[0.0008134656,0.0001254813,0.04505121,0.00001603381,0.000004224353,0.000003832388,0.0002102186,0.005901143,0.9457445,0.001788659,0.0002666975,0.0000745283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969949,0.0003130941,0.00006572573,0.001640893,0.00001692588,0.000597612,0.000006883079,0.000006554988,0.0003574455],"genre_scores_gemma":[0.9991278,0.0003703113,0.0002043207,0.0001372276,0.000008361047,0.00005361024,0.00002891012,0.000004257319,0.00006519176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04450405,"threshold_uncertainty_score":0.3226501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04426219727895934,"score_gpt":0.3473413482200487,"score_spread":0.3030791509410893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}