{"id":"W2089991249","doi":"10.1371/journal.pgen.1003498","title":"RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft","keywords":"Biology; Epigenetics; DNA methylation; Genetics; RNA-Directed DNA Methylation; RNA; Small RNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002552571,0.0003117326,0.0002259644,0.00005331606,0.0002133017,0.00009904778,0.0004780272,0.0002625773,0.0002421735],"category_scores_gemma":[0.0002368203,0.0002388643,0.000140813,0.0001547447,0.0002090052,0.000006222445,0.0001361666,0.0001898213,0.0001837489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001903076,"about_ca_system_score_gemma":0.00009407623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003922305,"about_ca_topic_score_gemma":0.00006576783,"domain_scores_codex":[0.9979653,0.0002226639,0.0004541216,0.0005023145,0.00036779,0.0004878421],"domain_scores_gemma":[0.9984276,0.00009002251,0.0001163722,0.0008672848,0.0002938215,0.0002048698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001598163,0.0001142718,0.002185723,0.00001962688,0.00009274714,0.000001575283,0.00006503959,0.0002872215,0.9924314,0.00002845424,0.0008518296,0.003906152],"study_design_scores_gemma":[0.0004385418,0.0003432121,0.004588414,0.0000109948,0.00007094682,0.000002182023,0.00005280452,0.001556518,0.9772112,0.0006430059,0.01474949,0.0003326287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857247,0.007781195,0.002586954,0.0009526603,0.0003095683,0.0006904,0.00004316755,0.00003652143,0.001874817],"genre_scores_gemma":[0.9945009,0.00245705,0.001041331,0.0004766211,0.0006782589,0.0001311051,0.0002070072,0.00006782513,0.0004399215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01522011,"threshold_uncertainty_score":0.9740602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017822944163841,"score_gpt":0.2380084973636074,"score_spread":0.2201855531997663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}