{"id":"W2089997569","doi":"10.1007/s00424-014-1546-7","title":"Allosteric regulation of the P2X4 receptor channel pore dilation","year":2014,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institutes of Health","keywords":"Allosteric regulation; Biophysics; Chemistry; Desensitization (medicine); Receptor; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003912745,0.0001029926,0.0001613748,0.00004485904,0.00005581114,0.000004820533,0.0002740407,0.00002796316,0.00002099849],"category_scores_gemma":[0.000102557,0.00007055923,0.0001534835,0.00006648213,0.0001055578,0.000005791645,0.0001016885,0.000115123,0.000004155654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004249448,"about_ca_system_score_gemma":0.00002388051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001355522,"about_ca_topic_score_gemma":2.09269e-7,"domain_scores_codex":[0.9986957,0.0005822667,0.0003610844,0.0001298514,0.0001015656,0.0001295515],"domain_scores_gemma":[0.9990823,0.00002790991,0.0005308163,0.0002161886,0.0000976428,0.00004517794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490116,0.00002629282,0.0001420633,0.0000136929,0.00003993125,5.033844e-7,0.000151741,0.001809084,0.9903491,0.00005852704,0.005757929,0.001502198],"study_design_scores_gemma":[0.002330716,0.002721285,0.2306557,0.0002051114,0.0001180457,0.0001648562,0.000196557,0.001102363,0.6772223,0.002008735,0.0828082,0.0004662354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936625,0.0002318051,0.003767367,0.0003415605,0.0003083898,0.00005513672,0.000003511505,0.000002622399,0.001627151],"genre_scores_gemma":[0.9982027,0.00006088538,0.0004684044,0.0001944152,0.000857769,3.213061e-7,0.00003093614,0.00001939865,0.0001652179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3131268,"threshold_uncertainty_score":0.2877322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007632434444128699,"score_gpt":0.1983897722013486,"score_spread":0.1907573377572199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}