{"id":"W2090006418","doi":"10.1515/bc.2008.072","title":"An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Androgen receptor; Prostate cancer; Transactivation; Protein kinase B; Cancer research; Androgen; PI3K/AKT/mTOR pathway; Dihydrotestosterone; Endocrinology; Internal medicine; LNCaP; Cell growth; Cancer; Biology; Chemistry; Signal transduction; Transcription factor; Cell biology; Medicine; Hormone; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545525,0.0002760981,0.0002816778,0.0003289877,0.0002319399,0.0004976836,0.0002860945,0.000214218,0.00172704],"category_scores_gemma":[0.0001417551,0.0002339363,0.0003515343,0.0004173227,0.000225188,0.0002576947,0.0001404912,0.0006507247,0.0006914327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006323222,"about_ca_system_score_gemma":0.0004469732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001897666,"about_ca_topic_score_gemma":0.00212748,"domain_scores_codex":[0.9998063,0.00002829738,0.0000237724,0.00003584124,0.00006936136,0.00003640747],"domain_scores_gemma":[0.9998715,0.00003123704,0.00002986236,0.00002051468,0.00002158514,0.00002528485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001762916,0.0001095931,0.0005414702,0.00004114108,0.00001037496,0.00004266062,0.00002088975,0.0001659031,0.9971018,0.0003574228,0.0001768033,0.001255603],"study_design_scores_gemma":[0.00003617043,0.0002495465,0.008799059,0.000005710546,0.0000221715,0.0002106778,0.00002768946,0.002230216,0.985786,0.0001065398,0.002517595,0.000008580234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857964,0.002510892,0.00541782,0.000159383,0.00006274497,0.00006715344,0.00194307,0.0002272675,0.003815274],"genre_scores_gemma":[0.9871525,0.001486737,0.004498471,0.000069028,0.00001248915,0.00007821046,0.002727428,0.00004311595,0.003931975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001897666,"threshold_uncertainty_score":0.005777538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04296117889697542,"score_gpt":0.3121011328747572,"score_spread":0.2691399539777818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}