{"id":"W2090015418","doi":"10.1074/jbc.m112.427864","title":"Ligand-dependent Conformational Changes in the Clamp Region of the Cardiac Ryanodine Receptor","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Ryanodine receptor; Chemistry; Biophysics; Förster resonance energy transfer; Ligand (biochemistry); Ryanodine receptor 2; Conformational change; Stereochemistry; Crystallography; Biochemistry; Receptor; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349741,0.0001460558,0.0002252369,0.00005319822,0.0001093613,0.0002544095,0.0001715231,0.0002597782,0.0009178699],"category_scores_gemma":[0.0002363935,0.0001317144,0.0001662455,0.00005476479,0.0002171343,0.0001974569,0.0001609743,0.0004525783,0.0002117929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826985,"about_ca_system_score_gemma":0.00009078933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002396704,"about_ca_topic_score_gemma":0.0002748467,"domain_scores_codex":[0.9999063,0.00001581336,0.000005916628,0.0000265323,0.00002809321,0.00001721862],"domain_scores_gemma":[0.9998788,0.00003397027,0.00003676251,0.0000126034,0.000008200383,0.00002971335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004739716,0.000004329376,0.00007018734,0.000009524241,0.000001738521,0.00002294573,0.000009486974,0.00003977463,0.9995434,0.00001877699,0.000008100713,0.0002242237],"study_design_scores_gemma":[0.0000188836,0.0001373276,0.006952457,0.000004340177,0.000007409255,0.0002467187,0.00003023877,0.0009958668,0.9910527,0.00003323614,0.0005101895,0.00001057552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983736,0.0002542608,0.0008997507,0.00004147809,0.000006766032,0.000004763059,0.00007250366,0.00002047391,0.0003262875],"genre_scores_gemma":[0.997851,0.0002152829,0.001120466,0.00006652516,0.00000444029,0.00001221518,0.0001325894,0.000009987451,0.0005874872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009178699,"threshold_uncertainty_score":0.003070593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775421592218577,"score_gpt":0.2467360151761893,"score_spread":0.2189817992540035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}