{"id":"W2090058558","doi":"10.1016/j.neuint.2005.12.006","title":"An interaction between benzodiazepines and neuroactive steroids at GABAA receptors in cultured hippocampal neurons","year":2006,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-Luc","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Allopregnanolone; Neuroactive steroid; Flumazenil; GABAA receptor; Pregnanolone; Benzodiazepine; Inverse agonist; Pharmacology; Chemistry; Endocrinology; Pregnenolone sulfate; Internal medicine; Allosteric regulation; Receptor; Neuroscience; Agonist; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004580308,0.0002807811,0.0006283131,0.0003145321,0.0007547544,0.00105459,0.0006045293,0.0005101769,0.001644265],"category_scores_gemma":[0.0007034896,0.0003661716,0.0005770554,0.0004661093,0.000479857,0.0008457329,0.0003938101,0.0006119725,0.0004651809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001266672,"about_ca_system_score_gemma":0.0007613552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009763543,"about_ca_topic_score_gemma":0.019632,"domain_scores_codex":[0.9995139,0.0001104179,0.00005216199,0.00008886723,0.0001019115,0.0001328114],"domain_scores_gemma":[0.9993283,0.0003682243,0.00004493667,0.00008226035,0.0001095159,0.00006689627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001358594,0.00006153697,0.000561695,0.0001839716,0.00004254419,0.0002776146,0.0002230798,0.00007898625,0.9946992,0.0002787886,0.0001235291,0.002110468],"study_design_scores_gemma":[0.0001663982,0.0007700075,0.01612703,0.00002780973,0.000103803,0.0004744526,0.0005831883,0.001155425,0.9777886,0.0001860898,0.002592952,0.000024079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916381,0.005318684,0.0007356648,0.000227556,0.00006020522,0.00001405885,0.0002565107,0.0000201554,0.001729125],"genre_scores_gemma":[0.9939266,0.001869777,0.0009154672,0.00007351839,0.00003471035,0.00002991888,0.0003520389,0.00001781104,0.002780087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009763543,"threshold_uncertainty_score":0.01941341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380846903475699,"score_gpt":0.3449049678782544,"score_spread":0.3110964988434974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}