{"id":"W2090080810","doi":"10.1017/s1355838202020289","title":"Delta ribozyme benefits from a good stability in vitro that becomes outstanding in vivo","year":2002,"lang":"en","type":"article","venue":"RNA","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Ribozyme; Biology; Hammerhead ribozyme; Mammalian CPEB3 ribozyme; Hairpin ribozyme; VS ribozyme; Nuclease; Cell biology; Transfection; In vivo; RNA; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069637,0.0001347281,0.0001733639,0.00005543997,0.0000232419,0.00002281356,0.0001810839,0.000133132,0.0002774417],"category_scores_gemma":[0.00003507543,0.0001318289,0.000068218,0.00008081555,0.00002677071,0.000007859991,0.00009095469,0.0001009827,0.00001777971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004033323,"about_ca_system_score_gemma":0.00001264893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150826,"about_ca_topic_score_gemma":0.002035331,"domain_scores_codex":[0.9990718,0.00004443878,0.0001936196,0.0003413879,0.00009560217,0.0002531917],"domain_scores_gemma":[0.9995753,0.00001943871,0.00004469496,0.0002901291,0.00001957475,0.00005090338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009674957,0.0001175312,0.08601675,0.000007311123,0.00002030381,0.0000106844,0.0002904679,0.00003769395,0.9089213,0.000007751268,0.0004336921,0.004039736],"study_design_scores_gemma":[0.0005256181,0.00007709033,0.01714586,0.00003177251,0.000005664687,0.00000166732,0.0002445405,0.0004740107,0.9801375,0.00008485466,0.001074238,0.0001972228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958036,0.002149623,0.00004051398,0.0001504394,0.0001069056,0.00009887366,0.0001523293,0.000007434647,0.001490294],"genre_scores_gemma":[0.9989793,0.0004474649,0.0001112242,0.000161196,0.00007152809,0.00001297389,0.0000500438,0.00001159819,0.0001546218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07121613,"threshold_uncertainty_score":0.5375828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03675852383226687,"score_gpt":0.2388788389404873,"score_spread":0.2021203151082204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}