{"id":"W2090080810","doi":"10.1017/s1355838202020289","title":"Delta ribozyme benefits from a good stability in vitro that becomes outstanding in vivo","year":2002,"lang":"en","type":"article","venue":"RNA","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Ribozyme; Biology; Hammerhead ribozyme; Mammalian CPEB3 ribozyme; Hairpin ribozyme; VS ribozyme; Nuclease; Cell biology; Transfection; In vivo; RNA; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319273,0.0003007304,0.0002403253,0.0001436592,0.00008398403,0.0003228521,0.0001328015,0.0002716439,0.0006879409],"category_scores_gemma":[0.0002691656,0.0001324391,0.0001568658,0.00009443163,0.0001954409,0.0001590015,0.0001833185,0.00039391,0.0003121003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332224,"about_ca_system_score_gemma":0.0001213535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009760281,"about_ca_topic_score_gemma":0.000137838,"domain_scores_codex":[0.99989,0.00002290468,0.00001419869,0.00002635629,0.00003074136,0.00001583163],"domain_scores_gemma":[0.9997975,0.00005923259,0.00004697051,0.00002911863,0.00003170543,0.00003551948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002393727,0.000002736389,0.0001147356,0.000009638962,0.000001766439,0.00002075169,0.000004080381,0.00003053735,0.9990991,0.00007922344,0.000006478172,0.0006070192],"study_design_scores_gemma":[0.000003709001,0.0001623087,0.001228558,0.000001561133,0.000007933709,0.0003499074,0.000006059032,0.0003253777,0.9971103,0.00005788088,0.0007443951,0.000002036892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824714,0.00164792,0.01331409,0.00009587774,0.00003090817,0.00001526678,0.0001878911,0.0001614694,0.002075088],"genre_scores_gemma":[0.9948539,0.000273388,0.003028702,0.00002890207,0.000007979459,0.000009482424,0.0002718234,0.00002531011,0.001500561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006879409,"threshold_uncertainty_score":0.002301335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03675852383226687,"score_gpt":0.2388788389404873,"score_spread":0.2021203151082204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}