{"id":"W2090087259","doi":"10.1161/01.atv.0000214981.58499.32","title":"Homocysteine Activates cAMP-response Element Binding Protein in HepG2 Through cAMP/PKA Signaling Pathway","year":2006,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"CREB; Hyperhomocysteinemia; CREB1; Endocrinology; Internal medicine; Protein kinase A; Adenylyl cyclase; Phosphorylation; Homocysteine; Signal transduction; Transcription factor; Cyclic AMP Response Element-Binding Protein; Chemistry; Biology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137603,0.000348422,0.0002162317,0.0002138382,0.0002823486,0.000225875,0.00011256,0.0001753686,0.003776825],"category_scores_gemma":[0.0001110912,0.0001115604,0.0002356747,0.0001862476,0.0001851233,0.0001248463,0.0001663185,0.0003602798,0.00149957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826586,"about_ca_system_score_gemma":0.0002226631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00263005,"about_ca_topic_score_gemma":0.003736462,"domain_scores_codex":[0.9998971,0.00003073712,0.000007669704,0.00001427321,0.00002321466,0.00002701585],"domain_scores_gemma":[0.9999444,0.00001657256,0.000007102954,0.00001068565,0.000009376909,0.00001174987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004579608,0.00008324923,0.0002204139,0.00007013887,0.00000811667,0.0000898895,0.00002405989,0.00005338642,0.9974146,0.00006833504,0.0002197316,0.001290102],"study_design_scores_gemma":[0.0001631711,0.0005885314,0.007308647,0.00001699854,0.000028244,0.0004628504,0.00008637233,0.001965826,0.9840541,0.0001226435,0.005192055,0.00001045603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833049,0.003786109,0.003452829,0.0005042626,0.0001515383,0.00007011375,0.001542567,0.0002167099,0.006970992],"genre_scores_gemma":[0.9868029,0.00140047,0.002529604,0.00009848537,0.00004295198,0.00007174399,0.002251722,0.0000332629,0.006768872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003776825,"threshold_uncertainty_score":0.01263469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03784348336812919,"score_gpt":0.3002489008785642,"score_spread":0.2624054175104349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}