{"id":"W2090109075","doi":"10.1111/j.1538-7836.2006.02118.x","title":"Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain","year":2006,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Canadian Blood Services; Heart and Stroke Foundation of Canada","keywords":"Immunology; Immune tolerance; Nasal administration; Immune system; Medicine; Splenocyte; Antibody; Antigen; Adoptive cell transfer; Immunotherapy; Titer; Cytokine; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608388,0.0003486965,0.0002293365,0.0001309535,0.0001516534,0.0003352069,0.0002403636,0.0004423144,0.002560317],"category_scores_gemma":[0.000263447,0.0001661712,0.0003578577,0.00006430556,0.0002455708,0.0002378756,0.0003403455,0.001274488,0.0005036694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002467292,"about_ca_system_score_gemma":0.0001724462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002443842,"about_ca_topic_score_gemma":0.0002175309,"domain_scores_codex":[0.9998407,0.00003204389,0.000006692371,0.00002765058,0.00002306466,0.00006978155],"domain_scores_gemma":[0.9998631,0.00002935767,0.00002937957,0.00003651636,0.00001261327,0.00002899219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009855741,0.0001929488,0.0002633184,0.00005335757,0.00001309266,0.0001086226,0.00002975438,0.00009364099,0.9933624,0.0003243786,0.0001137986,0.004458992],"study_design_scores_gemma":[0.0002179988,0.004655635,0.006089005,0.00002035346,0.00004472036,0.001145447,0.00007205173,0.001074639,0.9829201,0.0002259475,0.003525997,0.000008057287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967819,0.0004279264,0.001224147,0.00006388676,0.00004058771,0.00003164757,0.00005416572,0.00004042161,0.001335245],"genre_scores_gemma":[0.9977798,0.000180818,0.0005294775,0.00005961652,0.00002174222,0.00002377921,0.00009211457,0.00001204075,0.001300573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002560317,"threshold_uncertainty_score":0.008565128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06273817888369312,"score_gpt":0.3450882511441661,"score_spread":0.282350072260473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}