{"id":"W2090109075","doi":"10.1111/j.1538-7836.2006.02118.x","title":"Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain","year":2006,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Canadian Blood Services; Heart and Stroke Foundation of Canada","keywords":"Immunology; Immune tolerance; Nasal administration; Immune system; Medicine; Splenocyte; Antibody; Antigen; Adoptive cell transfer; Immunotherapy; Titer; Cytokine; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080545,0.0002103229,0.0006675149,0.0001493731,0.000208528,0.00005234654,0.0001665597,0.000124454,0.0002731779],"category_scores_gemma":[0.00007635741,0.0001195883,0.0002495624,0.0003504966,0.00009363522,0.0002001316,0.0000732295,0.0003052012,0.0000136893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078472,"about_ca_system_score_gemma":0.000121761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000183002,"about_ca_topic_score_gemma":0.00003368004,"domain_scores_codex":[0.9979611,0.00009776558,0.0007123384,0.0002049412,0.0006949268,0.0003289172],"domain_scores_gemma":[0.9988447,0.00008798133,0.0002735029,0.000280197,0.0003125481,0.0002010579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004327176,0.002758414,0.1247086,0.0003916793,0.001827584,0.0001299013,0.01669978,0.0001438274,0.6769144,0.0003400373,0.02554888,0.1462097],"study_design_scores_gemma":[0.004035272,0.003453973,0.711499,0.0004212541,0.0002606237,0.000122553,0.001432503,0.000007350673,0.252899,0.0001413014,0.02548782,0.000239395],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756551,0.001011335,0.0002676142,0.02196842,0.0003337046,0.0005333581,0.00006175333,0.000009500046,0.0001591702],"genre_scores_gemma":[0.9960361,0.0004781295,0.002351785,0.0002450946,0.0007051369,0.000009446396,0.00000440081,0.00002385927,0.0001461232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5867904,"threshold_uncertainty_score":0.4876668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06273817888369312,"score_gpt":0.3450882511441661,"score_spread":0.282350072260473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}