{"id":"W2090112346","doi":"10.1016/j.ejca.2011.01.017","title":"Des-γ-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway","year":2011,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"","keywords":"MAPK/ERK pathway; Kinase; Chemistry; Cell growth; Signal transduction; Cancer research; Molecular biology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001260527,0.0002003459,0.0002108822,0.00005886222,0.00009599113,0.0000375626,0.0004067752,0.00005736457,0.00005381014],"category_scores_gemma":[0.00003934595,0.0001443744,0.0001499565,0.0001139997,0.00008372804,0.00002699379,0.0001141781,0.0003424846,0.000005765489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004072515,"about_ca_system_score_gemma":0.0001543738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000125854,"about_ca_topic_score_gemma":0.00001850978,"domain_scores_codex":[0.9983214,0.000553336,0.0003787819,0.0002292354,0.0002345265,0.000282684],"domain_scores_gemma":[0.9991213,0.00000721353,0.0003953017,0.0002243534,0.0001376007,0.0001142277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536849,0.000174195,0.0004684453,0.00002460109,0.00005757637,0.0001515443,0.0003112434,0.000006017392,0.9954741,0.00001055128,0.000197143,0.002970884],"study_design_scores_gemma":[0.001005667,0.00050542,0.0003788921,0.0001034001,0.00002878035,0.00001730655,0.00008277987,0.00003890073,0.995195,0.00008572731,0.002374034,0.0001841371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833135,0.01480462,0.0007858726,0.00003579504,0.0001864315,0.0003226553,0.000009993559,0.000004587674,0.0005365131],"genre_scores_gemma":[0.9982892,0.0005365963,0.0005070758,0.00008348808,0.0003155074,0.00001627501,0.000001687684,0.00004664558,0.0002034819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01497572,"threshold_uncertainty_score":0.5887419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611514510187926,"score_gpt":0.2303416125822458,"score_spread":0.2042264674803666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}