{"id":"W2090119672","doi":"10.1016/j.molimm.2012.10.043","title":"Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria","year":2012,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"Medicinska Forskningsrådet; Umeå Universitet; Kempe Foundation; Public Health Agency of Canada","keywords":"Francisella tularensis; Vaccination; Tularemia; Attenuated vaccine; Biology; Microbiology; Virulence; Virology; Immunity; Pathogen; Immunology; Immune system; Immunization; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004599864,0.0002208174,0.0005148209,0.0002051718,0.00006297112,0.000006920673,0.0001703192,0.0002815951,0.00001001536],"category_scores_gemma":[0.0001215211,0.0001943063,0.00008530133,0.0002908935,0.0001429694,0.00002211688,0.0001193154,0.0001391731,5.11909e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002585077,"about_ca_system_score_gemma":0.00007921145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001792673,"about_ca_topic_score_gemma":0.00004183619,"domain_scores_codex":[0.9984542,0.0002774691,0.0004440068,0.0002795058,0.000240664,0.0003042181],"domain_scores_gemma":[0.9984919,0.00002593081,0.000394652,0.0004310301,0.0005989277,0.00005759467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001513413,0.0001065742,0.007975395,0.000246458,0.0004493554,0.000002864035,0.0004615208,0.0000985552,0.9859449,0.00002727557,4.173645e-7,0.003173231],"study_design_scores_gemma":[0.0009810725,0.001839165,0.07111716,0.0002035395,0.00009410224,0.00003618707,0.000288676,0.0000186535,0.9252252,0.000004745964,0.00001802387,0.0001734553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863351,0.007987489,0.004945855,0.00001293444,0.0001032244,0.0005506921,0.00003410312,0.000007027337,0.00002357262],"genre_scores_gemma":[0.998341,0.0003878478,0.00113496,0.000006365465,0.00001873419,0.00002200895,0.00005030423,0.00003589655,0.000002891199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06314176,"threshold_uncertainty_score":0.7923581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115897272438109,"score_gpt":0.239521981186376,"score_spread":0.2183630084619949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}