{"id":"W2090119792","doi":"10.1016/j.clinthera.2014.08.005","title":"Safety, Tolerability and Pharmacokinetics of Trimebutine 3-Thiocarbamoylbenzenesulfonate (GIC-1001) in a Randomized Phase I Integrated Design Study: Single and Multiple Ascending Doses and Effect of Food in Healthy Volunteers","year":2014,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inversago Pharma (Canada); BioPhage Pharma (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Tolerability; Placebo; Adverse effect; Crossover study; Randomized controlled trial; Cmax; Anesthesia; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002560278,0.001721976,0.002135294,0.0006466555,0.0005072842,0.000843561,0.0009037284,0.001803797,0.003155342],"category_scores_gemma":[0.002156023,0.001196364,0.001527892,0.0005379586,0.001892016,0.001186784,0.0003300086,0.00258469,0.000731936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007881325,"about_ca_system_score_gemma":0.001243487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231905,"about_ca_topic_score_gemma":0.001844165,"domain_scores_codex":[0.9984779,0.0009030151,0.00006734963,0.0002460762,0.0001143669,0.0001912547],"domain_scores_gemma":[0.9986388,0.0003553994,0.0002814847,0.0001798944,0.0001088894,0.0004355539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9418862,0.01762914,0.001442884,0.0001421239,0.000368029,0.00004820428,0.00008948334,0.0006192244,0.02066281,0.00005924537,0.0002977097,0.01675493],"study_design_scores_gemma":[0.340743,0.6407858,0.01070587,0.00001581209,0.0005498424,0.00007563583,0.00005226819,0.001024778,0.005412872,0.00008647427,0.0005061948,0.00004145988],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973835,0.0007566863,0.0004559076,0.00008452227,0.00005816759,0.0005920009,0.0002874227,0.00005416559,0.0003276212],"genre_scores_gemma":[0.9957112,0.000553947,0.001022928,0.0002289226,0.0001552988,0.0007942449,0.0004592831,0.00003625831,0.00103805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003155342,"threshold_uncertainty_score":0.01354021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07788883207652543,"score_gpt":0.3927934260976332,"score_spread":0.3149045940211078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}