{"id":"W2090119792","doi":"10.1016/j.clinthera.2014.08.005","title":"Safety, Tolerability and Pharmacokinetics of Trimebutine 3-Thiocarbamoylbenzenesulfonate (GIC-1001) in a Randomized Phase I Integrated Design Study: Single and Multiple Ascending Doses and Effect of Food in Healthy Volunteers","year":2014,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inversago Pharma (Canada); BioPhage Pharma (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Tolerability; Placebo; Adverse effect; Crossover study; Randomized controlled trial; Cmax; Anesthesia; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007152907,0.0002529126,0.001858742,0.0001664695,0.00002917456,0.000009709584,0.0000719411,0.0001305784,0.00000370032],"category_scores_gemma":[0.005524742,0.0001934753,0.0001134009,0.0002830135,0.0006511936,0.00004234319,0.00006468443,0.0004520798,9.763747e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002900683,"about_ca_system_score_gemma":0.00005768589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009747224,"about_ca_topic_score_gemma":0.00006934498,"domain_scores_codex":[0.9950969,0.00247072,0.00157349,0.0004181648,0.0001829143,0.0002578142],"domain_scores_gemma":[0.9880907,0.01112066,0.0002986668,0.0002275637,0.0001057632,0.0001566645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3713228,0.004040897,0.579526,0.0004483398,0.00016726,0.000003906159,0.000721929,0.0000718885,0.003355088,0.00001722067,6.513993e-7,0.04032402],"study_design_scores_gemma":[0.7156367,0.05331836,0.1218065,0.000602158,0.000701111,0.00001619248,0.0005195405,0.1041234,0.002572485,0.0004331984,0.00003524374,0.0002352002],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940171,0.001413092,0.002049898,0.0002747207,0.00006872874,0.002129471,0.000009839107,0.00001931272,0.00001788883],"genre_scores_gemma":[0.9978962,0.0005443544,0.001322253,0.0001816203,0.0000167364,0.00001191923,0.000005951781,0.00001917309,0.000001810931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4577195,"threshold_uncertainty_score":0.7889693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07788883207652543,"score_gpt":0.3927934260976332,"score_spread":0.3149045940211078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}