{"id":"W2090122150","doi":"10.1016/j.jconrel.2006.09.007","title":"Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new Polymer-Lipid Hybrid Nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer","year":2006,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemosensitizer; Doxorubicin; Pharmacology; Chemistry; Cancer cell; Cytotoxic T cell; Multiple drug resistance; Drug delivery; Clonogenic assay; Chemotherapy; Cancer; Apoptosis; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622119,0.0002835519,0.001466431,0.0001625052,0.00006319591,0.00001100498,0.00008524017,0.00008110934,0.00005148401],"category_scores_gemma":[0.00004137751,0.0001862154,0.0005192572,0.000105387,0.0001128413,0.0000814296,0.000005348579,0.00009390924,4.459039e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112089,"about_ca_system_score_gemma":0.0004486975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005559202,"about_ca_topic_score_gemma":0.0001344812,"domain_scores_codex":[0.9977655,0.00004618513,0.001245542,0.0002037497,0.0004153149,0.0003236926],"domain_scores_gemma":[0.9977617,0.0003394634,0.0009511507,0.0001805802,0.0004656886,0.000301387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06262919,0.001097053,0.0002054664,0.0001526161,0.0005503349,0.0001473652,0.0001215407,0.000275979,0.9193168,0.00003491927,0.0004232458,0.01504547],"study_design_scores_gemma":[0.06498739,0.002102772,0.0003101926,0.0004455183,0.001684987,0.000102708,0.0001613943,0.001094146,0.928157,0.00006508244,0.0007178684,0.0001709373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767976,0.01964619,0.001146708,0.001053459,0.0002000474,0.0008050301,0.0002898813,0.00001103521,0.00005003691],"genre_scores_gemma":[0.9950817,0.001841338,0.0005969053,0.00006207215,0.0003468929,0.00001723701,0.000009871682,0.00003523043,0.002008815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828402,"threshold_uncertainty_score":0.7593645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004367141155643735,"score_gpt":0.229252685957034,"score_spread":0.2248855448013902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}