{"id":"W2090139929","doi":"10.1089/gtmb.2010.0027","title":"Evaluation of the Contribution of the Three Breast Cancer Susceptibility Genes <i>CHEK2</i> , <i>STK11</i> , and <i>PALB2</i> in Non- <i>BRCA1/2</i> French Canadian Families with High Risk of Breast Cancer","year":2010,"lang":"en","type":"article","venue":"Genetic Testing and Molecular Biomarkers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"PALB2; CHEK2; STK11; Breast cancer; Genetics; Biology; Cancer; Cancer research; Mutation; Germline mutation; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008482838,0.0002171698,0.0002276583,0.00006559287,0.0001263158,0.00001291521,0.0002568466,0.0001774687,0.000007533672],"category_scores_gemma":[0.0002119476,0.000151694,0.00006591011,0.0004532691,0.0007398002,0.000005884422,0.000124399,0.0001516665,3.906677e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007391685,"about_ca_system_score_gemma":0.001361172,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1803663,"about_ca_topic_score_gemma":0.483889,"domain_scores_codex":[0.9983085,0.0002160494,0.0003696359,0.0004316191,0.0004017504,0.000272484],"domain_scores_gemma":[0.9980135,0.00004524471,0.0003783062,0.0005899875,0.0008871789,0.00008577926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002935543,0.00001787363,0.514154,0.0000273701,0.000100589,1.939119e-7,0.00003830148,0.001113247,0.4613811,0.000001425362,0.00002485979,0.02311175],"study_design_scores_gemma":[0.0009761348,0.00004272405,0.7563373,0.0001009822,0.000310941,0.00003100129,0.00005106588,0.0007482509,0.2411581,0.00007416667,0.00002641561,0.0001429311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951811,0.002704911,0.00007382346,0.0003388603,0.0001990883,0.0006561096,0.0007720278,0.000003338467,0.00007072044],"genre_scores_gemma":[0.9986591,0.0002179442,0.0008704176,0.00008720896,0.00003935732,0.00009019105,0.00001121226,0.00002249581,0.000002116449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3035227,"threshold_uncertainty_score":0.8250917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005918345747812042,"score_gpt":0.2280972687952946,"score_spread":0.2221789230474826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}