{"id":"W2090142821","doi":"10.1021/ja056692e","title":"Asymmetric Synthesis of All-Carbon Benzylic Quaternary Stereocenters via Cu-Catalyzed Conjugate Addition of Dialkylzinc Reagents to 5-(1-Arylalkylidene) Meldrum's Acids","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Stereocenter; Chemistry; Phosphoramidite; Conjugate; Reagent; Catalysis; Electrophile; Enantioselective synthesis; Organic chemistry; Carbon fibers; Combinatorial chemistry; Medicinal chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005521053,0.0003338709,0.001139559,0.000160161,0.00005551544,0.00002412506,0.001084121,0.0001395346,0.00006250806],"category_scores_gemma":[0.0006135502,0.0002490708,0.001575482,0.001405259,0.0003779281,0.0001240609,0.000294787,0.0003538648,0.000003422733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413726,"about_ca_system_score_gemma":0.00008132641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135343,"about_ca_topic_score_gemma":0.000004106273,"domain_scores_codex":[0.9966426,0.00009197365,0.001415645,0.0003235453,0.00110939,0.0004168367],"domain_scores_gemma":[0.9951743,0.0008881296,0.002844295,0.0006225098,0.0002655539,0.000205141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002784856,0.0004924948,0.01610674,0.0001160127,0.001041119,0.00000508556,0.0001315622,0.00002491017,0.9429814,0.00000198358,0.00360758,0.03521262],"study_design_scores_gemma":[0.0004899413,0.00005053654,0.004893795,0.0002178801,0.0007211111,0.00003104396,0.0003793667,0.0002014346,0.9923254,0.00006663718,0.0003717715,0.000251046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972617,0.0003056521,0.0001604414,0.0005548852,0.0000938553,0.0000810062,0.0001189082,0.00001614408,0.001407381],"genre_scores_gemma":[0.9978641,0.0002515464,0.001242489,0.0001986087,0.000311219,0.000009657966,0.00001659147,0.00004790299,0.00005787716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04934403,"threshold_uncertainty_score":0.9999961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008744276349553467,"score_gpt":0.2284808262462884,"score_spread":0.2197365498967349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}