{"id":"W2090170014","doi":"10.1371/journal.pgen.1003873","title":"Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; McGill University Health Centre; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; McGill University","keywords":"Biology; Genomic imprinting; Imprinting (psychology); X-inactivation; Genetics; X chromosome; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009264958,0.0003970322,0.0002243963,0.0004819939,0.000127805,0.0002347478,0.00025399,0.0002561441,0.002296401],"category_scores_gemma":[0.0001467871,0.0002792107,0.0001572729,0.0001409643,0.0003191114,0.0001327917,0.0003411856,0.0004751164,0.0003636891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320917,"about_ca_system_score_gemma":0.0001886817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007138732,"about_ca_topic_score_gemma":0.001086529,"domain_scores_codex":[0.9998627,0.00001964202,0.00001336379,0.00004587371,0.00003008546,0.00002844796],"domain_scores_gemma":[0.9997813,0.00002805141,0.00009531593,0.00002221546,0.000006390759,0.00006669346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008486823,0.0000103174,0.0004247692,0.00001538653,0.000004762431,0.0001124393,0.00001568348,0.00003856986,0.9982648,0.00008984617,0.00001794312,0.0009206488],"study_design_scores_gemma":[0.00001569405,0.0002192034,0.0168456,0.000007930421,0.00002187648,0.001222472,0.00004348893,0.0004206485,0.9796311,0.00008450762,0.001482363,0.000005248997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961082,0.0006768242,0.001361963,0.00007478841,0.00001682717,0.00001203626,0.0004462263,0.0001306249,0.001172483],"genre_scores_gemma":[0.9936156,0.0006178764,0.0009930598,0.00003333143,0.000007900309,0.00001791828,0.0002593164,0.00006898324,0.004385963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296401,"threshold_uncertainty_score":0.007682204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629100479621257,"score_gpt":0.2543426659166399,"score_spread":0.2380516611204273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}