{"id":"W2090170014","doi":"10.1371/journal.pgen.1003873","title":"Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; McGill University Health Centre; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; McGill University","keywords":"Biology; Genomic imprinting; Imprinting (psychology); X-inactivation; Genetics; X chromosome; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006179458,0.0001286971,0.0001377198,0.00006195862,0.00002629035,0.00002003117,0.00008997396,0.0001274009,0.00001876922],"category_scores_gemma":[0.00007255531,0.0001278925,0.00003128683,0.00008914866,0.00007433411,0.000006020416,0.0001138302,0.00005927118,0.000004705131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001531519,"about_ca_system_score_gemma":0.0000256508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002027712,"about_ca_topic_score_gemma":0.00004676637,"domain_scores_codex":[0.9991927,0.0000453853,0.0002348654,0.000237593,0.0001137818,0.00017565],"domain_scores_gemma":[0.9995353,0.00002197147,0.0001007203,0.0001922358,0.00008831447,0.00006146312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000130072,0.00008484154,0.2345861,0.00003581839,0.00001470916,4.534309e-7,0.00006436789,0.00005247666,0.7642723,0.00001507786,0.000003384301,0.0008574922],"study_design_scores_gemma":[0.0003716044,0.0001716868,0.1728866,0.00002074501,0.000008984179,0.000001133393,0.00005866082,0.001005795,0.8250736,0.0002206422,0.00006245972,0.0001180908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997482,0.001817678,0.0001257917,0.00003880929,0.00004316347,0.0003020186,0.000008465639,0.000005439309,0.000176639],"genre_scores_gemma":[0.9982655,0.001085609,0.0004365124,0.0000174855,0.00005298809,0.00002383821,0.00007363519,0.00001948757,0.00002494664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06169946,"threshold_uncertainty_score":0.5215303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629100479621257,"score_gpt":0.2543426659166399,"score_spread":0.2380516611204273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}