{"id":"W2090176557","doi":"10.1073/pnas.0700776104","title":"Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":527,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Genève; Fondation Leenaards; Oncosuisse; Karolinska Institutet; York University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"GLI1; Melanoma; Cancer research; Hedgehog signaling pathway; Hedgehog; Protein kinase B; Sonic hedgehog; Biology; Signal transduction; Metastasis; PI3K/AKT/mTOR pathway; Melanocyte; Cancer; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03965086181825275,"score_gpt":0.3037061820585769,"score_spread":0.2640553202403242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}