{"id":"W2090184902","doi":"10.1016/j.ijpara.2015.01.003","title":"Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages","year":2015,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; March of Dimes Foundation; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; Canadian Institutes of Health Research","keywords":"Biology; Rhoptry; Toxoplasma gondii; Major histocompatibility complex; Antigen presentation; Antigen processing; Intracellular parasite; Antigen; MHC class I; Cell biology; Interferon gamma; Immune system; Molecular biology; Immunology; T cell; Antibody; Plasmodium falciparum; Apicomplexa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003568995,0.0002482992,0.0004852506,0.0005666479,0.0001142986,0.00002517133,0.0006547114,0.0002537807,0.0001284584],"category_scores_gemma":[0.0004867118,0.0001868201,0.0001091514,0.0001353994,0.0003461268,0.0002047964,0.0002781958,0.0006001544,0.00002914775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071307,"about_ca_system_score_gemma":0.0001834034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005925517,"about_ca_topic_score_gemma":0.0001886947,"domain_scores_codex":[0.998213,0.0002946469,0.000586069,0.000306413,0.0001493543,0.0004505203],"domain_scores_gemma":[0.9983109,0.0003053682,0.0003805917,0.0001613665,0.0007732319,0.00006860132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01405029,0.0003662927,0.0328762,0.00001990619,0.0007545287,0.0001808605,0.002075658,0.0002776843,0.9408731,0.0004373775,0.00598995,0.002098168],"study_design_scores_gemma":[0.007505799,0.003298619,0.008168078,0.0002730816,0.00002878055,0.002331037,0.001550771,0.00003998869,0.9666203,0.0007367256,0.009186404,0.0002604624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942078,0.0007173058,0.001448147,0.0008950535,0.001872511,0.0002874191,0.00008281682,0.00002965878,0.0004592909],"genre_scores_gemma":[0.9978529,0.00006845522,0.0007178313,0.00004772334,0.00007542097,0.00005594049,0.0000894612,0.00002610404,0.001066125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02574717,"threshold_uncertainty_score":0.7618302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02999788890135891,"score_gpt":0.3499858081164385,"score_spread":0.3199879192150796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}