{"id":"W2090184902","doi":"10.1016/j.ijpara.2015.01.003","title":"Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages","year":2015,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; March of Dimes Foundation; National Institutes of Health; Canada Research Chairs; Canada Foundation for Innovation; Canadian Institutes of Health Research","keywords":"Biology; Rhoptry; Toxoplasma gondii; Major histocompatibility complex; Antigen presentation; Antigen processing; Intracellular parasite; Antigen; MHC class I; Cell biology; Interferon gamma; Immune system; Molecular biology; Immunology; T cell; Antibody; Plasmodium falciparum; Apicomplexa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003092428,0.000458993,0.0003023778,0.0001358345,0.0001735294,0.0004167697,0.0001978104,0.0004190161,0.001416986],"category_scores_gemma":[0.0002932215,0.0002145612,0.0003144421,0.000125476,0.0002510793,0.0001905206,0.0002668333,0.0009547062,0.0004370787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746857,"about_ca_system_score_gemma":0.0002085748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215226,"about_ca_topic_score_gemma":0.0001945956,"domain_scores_codex":[0.9995865,0.0001196664,0.00003881692,0.00003531319,0.00007087236,0.0001487145],"domain_scores_gemma":[0.9997644,0.00009829097,0.00003532922,0.00003616557,0.00002428704,0.00004151627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004640337,0.00005011827,0.0001598186,0.00003476455,0.000005011811,0.00008290369,0.00001809436,0.00003762484,0.9985421,0.00005402997,0.00001655658,0.0005350001],"study_design_scores_gemma":[0.0001322773,0.0008160227,0.003588398,0.000009960089,0.0000242485,0.0002456321,0.00006273504,0.0006240032,0.9936891,0.00009638284,0.0007071628,0.000004055145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976063,0.0006205508,0.0007358001,0.00005552159,0.00004679245,0.00001739973,0.00005266991,0.00001384198,0.0008510847],"genre_scores_gemma":[0.9973048,0.0003203673,0.0007060368,0.00005616851,0.00002132487,0.00002714912,0.000177432,0.00001131752,0.001375443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416986,"threshold_uncertainty_score":0.004740298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02999788890135891,"score_gpt":0.3499858081164385,"score_spread":0.3199879192150796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}