{"id":"W2090194270","doi":"10.1523/jneurosci.1920-04.2005","title":"Deleted in Colorectal Cancer Binding Netrin-1 Mediates Cell Substrate Adhesion and Recruits Cdc42, Rac1, Pak1, and N-WASP into an Intracellular Signaling Complex That Promotes Growth Cone Expansion","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University","keywords":"Netrin; Deleted in Colorectal Cancer; Growth cone; Cell biology; Biology; Filopodia; Axon guidance; CDC42; PAK1; RAC1; Actin; Axon; Signal transduction; Genetics; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006139106,0.0003886023,0.0001498367,0.0002025863,0.0002442223,0.0002408582,0.000153229,0.0002087013,0.001538308],"category_scores_gemma":[0.00009760923,0.0001788456,0.0002034826,0.00009354667,0.0001534383,0.0001125246,0.0001848549,0.0005032312,0.000360101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006961335,"about_ca_system_score_gemma":0.0003192027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002241637,"about_ca_topic_score_gemma":0.005216898,"domain_scores_codex":[0.9998707,0.00001480782,0.00001052725,0.00002858177,0.00004286255,0.00003251151],"domain_scores_gemma":[0.9999348,0.000005117324,0.00001697218,0.000004980547,0.000005636959,0.00003252591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003949965,0.000009827495,0.0002963205,0.00001785876,0.00000377807,0.0000643142,0.000004592733,0.00004439142,0.9990339,0.0000644952,0.00003954201,0.0003813217],"study_design_scores_gemma":[0.00002041992,0.000142678,0.01960841,0.000008245924,0.00002191305,0.000817643,0.00003625591,0.002463615,0.9719527,0.00003192033,0.004891119,0.000005189903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961715,0.0006021103,0.001373521,0.0001022372,0.00002124692,0.00002323662,0.0003033647,0.00003675283,0.001365993],"genre_scores_gemma":[0.9935674,0.0005245024,0.001951084,0.0000485693,0.000004175346,0.00003447349,0.0007106361,0.00001052424,0.003148664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002241637,"threshold_uncertainty_score":0.005146146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07485527383614367,"score_gpt":0.2967167059319334,"score_spread":0.2218614320957897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}