{"id":"W2090240368","doi":"10.1016/j.bmcl.2011.12.124","title":"γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Analgesic; Cannabinoid; Agonist; Tolerability; Cannabinoid receptor; Pharmacology; Solubility; Oral administration; Cannabinoid receptor type 2; Pharmacokinetics; Medicine; Receptor; Biochemistry; Organic chemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001253945,0.0004069019,0.0002514077,0.0002591301,0.0002069329,0.0003383378,0.0005954746,0.0003496855,0.001280869],"category_scores_gemma":[0.0001386622,0.0001291564,0.0001562379,0.0002238087,0.000216307,0.0003286363,0.0003112161,0.0005731032,0.0008189307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148973,"about_ca_system_score_gemma":0.0002941183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085862,"about_ca_topic_score_gemma":0.001856306,"domain_scores_codex":[0.9999354,0.000008159703,0.000005104503,0.00001788529,0.00001671308,0.0000166939],"domain_scores_gemma":[0.9999597,0.000005616402,0.000009003189,0.000004765893,0.000008743058,0.00001209113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005938091,0.0001124008,0.0001747073,0.0003367896,0.00001273845,0.0005883354,0.00009553443,0.0004330262,0.9429204,0.00251549,0.001328751,0.05088801],"study_design_scores_gemma":[0.000241858,0.00148212,0.001389904,0.00005506811,0.00006429788,0.00361452,0.0000766484,0.001504515,0.8948929,0.0004930695,0.09612234,0.00006279638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.88376,0.05834143,0.01839259,0.001375563,0.0002988894,0.0003407547,0.001317545,0.000676084,0.03549697],"genre_scores_gemma":[0.9541411,0.02225135,0.008027985,0.0005215709,0.00006646142,0.0001156435,0.0008805241,0.00005401018,0.01394142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280869,"threshold_uncertainty_score":0.004284978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01260506789490171,"score_gpt":0.247113860318478,"score_spread":0.2345087924235763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}