{"id":"W2090244231","doi":"10.1111/1567-1364.12014","title":"Homoisocitrate dehydrogenase from<i>Candida albicans</i>: properties, inhibition, and targeting by an antifungal pro-drug","year":2012,"lang":"en","type":"article","venue":"FEMS Yeast Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Fundacja na rzecz Nauki Polskiej; China Building Materials Academy","keywords":"Enzyme; Molecular mass; Biology; Biochemistry; Tetramer; Candida albicans; Escherichia coli; Enzyme assay; Recombinant DNA; Enzyme kinetics; Molecular biology; Dehydrogenase; Active site; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136091,0.000204812,0.0001680977,0.00006543456,0.0003309476,0.0001310771,0.0002483096,0.0002068639,0.0001029158],"category_scores_gemma":[0.0001841083,0.0001744761,0.00005845058,0.000220501,0.0004512111,0.00002736883,0.0003996171,0.0004949925,0.00004315456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002997227,"about_ca_system_score_gemma":0.0001616182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008263825,"about_ca_topic_score_gemma":0.00005468501,"domain_scores_codex":[0.9971934,0.0004087428,0.000221903,0.0005811105,0.0005912658,0.001003552],"domain_scores_gemma":[0.9987038,0.00001440573,0.00003733956,0.0003802307,0.0002459134,0.0006183005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423953,0.0002441362,0.003977723,0.00003654733,0.00003858869,0.000005892537,0.0001788052,3.031942e-7,0.9716147,0.00001972327,0.02234228,0.00139886],"study_design_scores_gemma":[0.0004793587,0.0001283807,0.0003915508,0.00002682515,0.000006139288,0.00001196027,0.0002838364,0.00005322014,0.9424181,0.00004722323,0.05591432,0.0002390769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890691,0.009079798,0.0001005126,0.0003485513,0.00004499515,0.0004337989,0.0001518933,0.00002195899,0.0007493924],"genre_scores_gemma":[0.9961233,0.0003378062,0.0002097857,0.0001385654,0.000566091,0.0001191927,0.0009453655,0.00005140959,0.001508465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03357203,"threshold_uncertainty_score":0.7114927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170898293602449,"score_gpt":0.2998143803593228,"score_spread":0.2681053974232983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}