{"id":"W2090244231","doi":"10.1111/1567-1364.12014","title":"Homoisocitrate dehydrogenase from<i>Candida albicans</i>: properties, inhibition, and targeting by an antifungal pro-drug","year":2012,"lang":"en","type":"article","venue":"FEMS Yeast Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Fundacja na rzecz Nauki Polskiej; China Building Materials Academy","keywords":"Enzyme; Molecular mass; Biology; Biochemistry; Tetramer; Candida albicans; Escherichia coli; Enzyme assay; Recombinant DNA; Enzyme kinetics; Molecular biology; Dehydrogenase; Active site; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008881518,0.0004509548,0.0003283973,0.0002213835,0.00009893466,0.000427159,0.0003648056,0.0002280648,0.0004639282],"category_scores_gemma":[0.0001108742,0.0001070498,0.0002863104,0.0005678288,0.0001256183,0.0001190716,0.0001260009,0.0004002984,0.0002976666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000441746,"about_ca_system_score_gemma":0.0003463083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984842,"about_ca_topic_score_gemma":0.002723419,"domain_scores_codex":[0.9998758,0.00001063494,0.000017341,0.00002645155,0.00004479727,0.0000250449],"domain_scores_gemma":[0.9999235,0.000005856906,0.00001927587,0.000009434938,0.00002436789,0.00001759522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073228,0.00001451245,0.0001907313,0.00006311217,0.000006675837,0.00004716305,0.000004906621,0.00006792017,0.9968418,0.00003491609,0.00007912839,0.002541921],"study_design_scores_gemma":[0.000007273606,0.00007725105,0.002826927,0.000004978765,0.00001498498,0.0003435409,0.000009893736,0.0003148173,0.9933565,0.00001527395,0.003022279,0.000006281984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719306,0.01235459,0.00738285,0.0002940616,0.00008089092,0.0001028886,0.004491123,0.0002633523,0.003099564],"genre_scores_gemma":[0.9768416,0.003989436,0.006831413,0.00008589215,0.00002193717,0.00004154923,0.008490062,0.00006098908,0.003637149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002984842,"threshold_uncertainty_score":0.005934954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170898293602449,"score_gpt":0.2998143803593228,"score_spread":0.2681053974232983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}