{"id":"W2090257361","doi":"10.1200/jco.2009.26.3343","title":"Randomized Phase II Trials: Inevitable or Inadvisable?","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Citation; Medicine; Clinical Oncology; Randomized controlled trial; Clinical trial; Library science; Oncology; Internal medicine; Cancer; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.2703559,0.0003184938,0.01227624,0.0001871111,0.0001299328,0.00003962218,0.00084268,0.001336998,0.006280933],"category_scores_gemma":[0.9639343,0.0001706164,0.002490527,0.0003105254,0.001185157,0.0002143743,0.0002474537,0.003996822,0.00004876322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005462613,"about_ca_system_score_gemma":0.002376643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000719749,"about_ca_topic_score_gemma":0.00002763737,"domain_scores_codex":[0.9531733,0.02393397,0.02093332,0.0004321638,0.0009417368,0.0005854763],"domain_scores_gemma":[0.1220139,0.8600588,0.01479864,0.0007204611,0.001367862,0.001040287],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.5091994,0.008544073,0.00003432042,0.00006174507,0.001126867,0.0003820971,0.00006697545,7.677347e-7,0.000271789,0.0830688,0.05380188,0.3434413],"study_design_scores_gemma":[0.357013,0.008091565,0.000009579047,0.00005645543,0.001112729,0.0001106588,0.0000252463,0.0001264894,0.0001188348,0.5504248,0.08276764,0.000143005],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5603195,0.0003533071,0.2669185,0.04050133,0.08191022,0.004706591,0.000118674,0.0001915751,0.04498032],"genre_scores_gemma":[0.04143352,0.0004268736,0.9456334,0.001961472,0.008635338,0.0000290849,5.165236e-7,0.00005165385,0.001828211],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.8361248,"threshold_uncertainty_score":0.9999595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8457395369729281,"score_gpt":0.7345951961345429,"score_spread":0.1111443408383852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}