{"id":"W2090266806","doi":"10.1158/0008-5472.can-09-3813","title":"Autotaxin Promotes Cancer Invasion via the Lysophosphatidic Acid Receptor 4: Participation of the Cyclic AMP/EPAC/Rac1 Signaling Pathway in Invadopodia Formation","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Autotaxin; Invadopodia; Lysophosphatidic acid; RAC1; Cancer cell; Cancer research; Metastasis; Cell biology; Cancer; Receptor; Biology; Signal transduction; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671194,0.0001277934,0.0001502296,0.00007984235,0.0002542152,0.00004516478,0.0004430597,0.0001596465,0.0001529374],"category_scores_gemma":[0.0005786746,0.00008088401,0.00007519429,0.0004865655,0.0002120948,0.00002422875,0.0001883922,0.0004812596,0.000007627204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004634769,"about_ca_system_score_gemma":0.000356388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092994,"about_ca_topic_score_gemma":0.00329379,"domain_scores_codex":[0.9981954,0.0003405437,0.0003404019,0.0002763397,0.0004568301,0.0003905066],"domain_scores_gemma":[0.9989508,0.00006486606,0.0001555894,0.0004721837,0.0002859783,0.00007054563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031288,0.00003736017,0.003999956,0.00005109564,0.00001185251,1.562512e-7,0.0009626587,0.0001730657,0.9858106,0.00006602718,0.0002279623,0.008556099],"study_design_scores_gemma":[0.000474257,0.00003507621,0.003318405,0.00008651945,0.000006582113,7.521188e-7,0.0001004801,0.000187586,0.9893912,0.0001902538,0.006108577,0.0001003021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956376,0.002334032,0.0001376731,0.0007509792,0.0004282608,0.0006336592,0.00002113268,0.000007098142,0.00004957763],"genre_scores_gemma":[0.9982077,0.0004627526,0.00009047436,0.0001063882,0.0004437531,0.0005277358,0.00003138623,0.00002189013,0.0001078488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008455797,"threshold_uncertainty_score":0.3298354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05095405975236725,"score_gpt":0.3513495029659159,"score_spread":0.3003954432135487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}