{"id":"W2090321716","doi":"10.1038/sj.clpt.6100510","title":"Human Abuse Liability of the Smoking Cessation Drug Varenicline in Smokers and Nonsmokers","year":2008,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Pfizer","keywords":"Varenicline; Placebo; Partial agonist; Drug; Abuse liability; Medicine; Pharmacology; Smoking cessation; Crossover study; Agonist; Nicotinic agonist; Clinical pharmacology; Amphetamine; Anesthesia; Nicotine; Psychiatry; Internal medicine; Receptor; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00096503,0.0001385874,0.000363849,0.00007312981,0.0001339602,0.000003438583,0.0001430956,0.0002147708,0.00008524687],"category_scores_gemma":[0.00003058847,0.000104092,0.0001394681,0.0002568287,0.0008810015,0.00005775245,0.00004671267,0.0006852038,5.359119e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007323134,"about_ca_system_score_gemma":0.0001015808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004053663,"about_ca_topic_score_gemma":0.00001361065,"domain_scores_codex":[0.9981772,0.0003782675,0.0007388386,0.0002892686,0.0002201975,0.0001962412],"domain_scores_gemma":[0.9989026,0.0003851698,0.0002471679,0.000275527,0.0001160487,0.00007355584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001423614,0.0005852844,0.9933276,0.00002297425,0.0001023672,0.000007412457,0.001069776,0.00001953072,0.003636287,0.000007138075,0.0003249989,0.0007542921],"study_design_scores_gemma":[0.003941114,0.0001489217,0.9899509,0.00003212029,0.0006346904,0.00001405203,0.0001151087,0.000174638,0.003855043,0.00007950314,0.0009596185,0.00009429134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958517,0.000101851,0.000009018277,0.002701698,0.0007848251,0.0004034105,0.000004264956,0.00003097701,0.0001122314],"genre_scores_gemma":[0.9917341,0.0004256725,0.00003822828,0.007524897,0.000145311,0.00001481723,0.000007775379,0.00001706994,0.00009211872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004823199,"threshold_uncertainty_score":0.424475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1133570821367069,"score_gpt":0.4271345216535918,"score_spread":0.3137774395168849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}