{"id":"W2090332697","doi":"10.1038/nrm827","title":"Adenovirus-5 E1A: paradox and paradigm","year":2002,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":307,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Biology; Adenoviridae; Transcription (linguistics); Cell biology; Transcription factor; Cancer research; Gene; Genetics; Genetic enhancement; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003500205,0.001242853,0.002261922,0.001652449,0.0008199766,0.002779888,0.002249671,0.004071493,0.001800583],"category_scores_gemma":[0.002119448,0.0004917727,0.0003989658,0.001597258,0.00405128,0.006228974,0.001298746,0.005502971,0.001661463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002682909,"about_ca_system_score_gemma":0.002115948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456534,"about_ca_topic_score_gemma":0.001674918,"domain_scores_codex":[0.9995763,0.0001156406,0.00004489058,0.00007659923,0.0001436925,0.00004289049],"domain_scores_gemma":[0.9988852,0.0007110509,0.00005568643,0.00004473182,0.000228021,0.00007520561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004190207,0.0001298496,0.0002486845,0.006473621,0.00007861505,0.0008851096,0.0002898165,0.001029995,0.005739795,0.1476422,0.1264017,0.7106616],"study_design_scores_gemma":[0.00003283533,0.00005056715,0.0001038911,0.0007958908,0.00002590594,0.0008638703,0.0001397019,0.0001221125,0.001182429,0.03447429,0.9621822,0.00002632369],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002174809,0.9918553,0.0008860092,0.004202038,0.001186387,0.000004281303,0.00001717498,0.00001478509,0.001616572],"genre_scores_gemma":[0.002473052,0.9910411,0.000684074,0.003556454,0.001007307,0.00001724914,0.00002569215,0.000005117739,0.001189951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004071493,"threshold_uncertainty_score":0.01946598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0314112104496015,"score_gpt":0.3500194866222386,"score_spread":0.3186082761726372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}