{"id":"W2090364875","doi":"10.1021/jm100478y","title":"Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Cocrystal; Chemistry; Lysine; Methyltransferase; Small molecule; Methylation; Biochemistry; Histone H3; Structure–activity relationship; Amino acid; In vitro; DNA; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003464304,0.0006106977,0.0003875384,0.0003069136,0.0001534004,0.000285534,0.0006654264,0.000432861,0.0007924621],"category_scores_gemma":[0.0001593503,0.0002700058,0.0003078552,0.0002320171,0.000191441,0.0002625295,0.0002466236,0.000536609,0.000522296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006906817,"about_ca_system_score_gemma":0.0003563958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103046,"about_ca_topic_score_gemma":0.003748822,"domain_scores_codex":[0.9999119,0.00001944279,0.000006278589,0.0000191373,0.00002288745,0.00002034718],"domain_scores_gemma":[0.9999439,0.000005856126,0.00001669965,0.000004348709,0.00001083718,0.00001844589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000600101,0.0004898153,0.0004243224,0.0004950864,0.00006793971,0.0002319383,0.0000539217,0.004857936,0.9397829,0.001550938,0.001528666,0.04991641],"study_design_scores_gemma":[0.0008991578,0.005565066,0.002958489,0.00005069123,0.0001477109,0.0009596644,0.00002642235,0.007968031,0.9341828,0.0004611115,0.0467222,0.00005872043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7909516,0.1215596,0.0622934,0.001871091,0.0003557547,0.001987395,0.00290701,0.00121672,0.01685739],"genre_scores_gemma":[0.9275047,0.03588396,0.02742008,0.000401719,0.00005177096,0.0003744276,0.001949182,0.00004848797,0.006365558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103046,"threshold_uncertainty_score":0.005011261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385351056385984,"score_gpt":0.2483575587743517,"score_spread":0.2345040482104918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}