{"id":"W2090364875","doi":"10.1021/jm100478y","title":"Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Cocrystal; Chemistry; Lysine; Methyltransferase; Small molecule; Methylation; Biochemistry; Histone H3; Structure–activity relationship; Amino acid; In vitro; DNA; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009571702,0.000182839,0.000317996,0.00005613942,0.00006607455,0.00001281512,0.0001589294,0.0003388874,0.00003722488],"category_scores_gemma":[0.001528711,0.0001502085,0.00009806736,0.0001021864,0.0001838601,0.00001196616,0.00003141557,0.0005988576,1.470111e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001184765,"about_ca_system_score_gemma":0.0001937692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000069461,"about_ca_topic_score_gemma":0.00000644523,"domain_scores_codex":[0.9987185,0.0001094435,0.000485581,0.0001937464,0.0003369657,0.0001557637],"domain_scores_gemma":[0.9986671,0.0001295648,0.0004566863,0.0002345601,0.0003338329,0.0001782203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403143,0.00006908277,0.002180397,0.000130248,0.00006233562,0.000008603828,0.00004308854,0.00002934046,0.9925011,0.000003323454,0.00003972419,0.004692414],"study_design_scores_gemma":[0.0006194895,0.0001966362,0.00419693,0.0000944955,0.0001146963,0.00009095875,0.00005805967,0.00003698725,0.9936937,0.0002376503,0.0005220603,0.0001383325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919517,0.00184644,0.005604116,0.0002771973,0.0001082812,0.0001178478,0.00001684785,0.000002790737,0.00007477737],"genre_scores_gemma":[0.994248,0.0002080428,0.004631234,0.000008348041,0.0008248852,0.000003603754,0.00000911164,0.00001837626,0.00004843739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004554081,"threshold_uncertainty_score":0.6125324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385351056385984,"score_gpt":0.2483575587743517,"score_spread":0.2345040482104918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}